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DOI: 10.1055/s-0036-1578768
Flavonoids From The Roots Of Artocarpus Heterophyllus And Their Inhibitory Activity Against Cathepsin K
As part of our project for discovering structurally interesting and bioactive phenolic compounds from Artocarpus plants (Moraceae), we performed a phytochemical investigation on Artocarpus heterophyllus. Four new flavonoids, artoheteroids A-D (1 – 4) were isolated from the roots of this plant. The structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All the isolates (1 – 4) were evaluated for their inhibitory activity against Cathepsin K, and compounds 1 – 3 exhibited significantly suppressive effect on Cathepsin K with IC50 values of 6.03, 12.52, 13.65µM, respectively.
Acknowledgements: This study was supported by National Natural Science Foundation of China (No. 81160509; 81360475), Young Scientist Development Program of Jiangxi Province (No. 20142BCB23024), and by Natural Science Foundation of Jiangxi Province (No. 20151BAB205074).