Planta Med 2016; 82 - PC22
DOI: 10.1055/s-0036-1578724

Mansoin F: TNF-α Inhibiting Heterotrimeric Flavonoid From Mansoa Hirsuta DC

PRV Campana 1, 2, CM Coleman 3, LP Sousa 1, MM Teixeira 4, D Ferreira 3, FC Braga 1
  • 1Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 – 901, Brazil
  • 2Serviço de Fitoquímica e Prospecção Farmacêutica, Fundação Ezequiel Dias, Belo Horizonte, MG, 30.510 – 010, Brazil
  • 3Department of Biomolecular Sciences, University of Mississippi, University, MS 38677, United States
  • 4Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31.270 – 901, Brazil

Mansoa hirsuta DC (Bignoniaceae) is a liana found in the Brazilian Atlantic forest. In a previous study we isolated two heterotrimeric glucosilated flavonoids comprising a flavanone core linked to two 1,3-diarylpropane C6-C3-C6 units, named mansoins A (1) and B (2) [1]. Continued investigation of the polyphenolic pool of the fruits of Mansoa hirsuta DC (Bignoniaceae) afforded a new member of this class of flavonoids. The structure and absolute configuration of mansoin F (3) were established by NMR analysis and electronic circular dichroism data. Mansoin F (3) was identified as triglucosylated heterotrimer, isomeric with mansoin A (1). Mansoin F (3) inhibited TNF-α release by LPS-stimulated THP-1 cells (IC50 of 19.3 ± 1.3µM) and along with mansoin A (1) reduced the phosphorylation levels of p-65-NF-κB, when assayed at 50µM. These results indicate that the potential anti-inflammatory properties of mansoin F (3) is probably due to inhibition of the NF-κB pathway.

Fig. 1

Acknowledgments: CNPq for financial support.

Reference: [1] Campana, et al. (2014)J Nat Prod, 77(4):824 – 830.