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DOI: 10.1055/s-0036-1578691
Brain Targeted Quercetin Loaded Polymeric Nanoparticles For The Treatment Of Brain Ischimia
Quercetin is a natural bioflavonoid largely used as traditional medicine. Its poor solubility with low bioavailability and side-effects at higher concentration limit its use. Thus, the idea behind the present study is to deliver the quercetin through a nanocarrier that overcomes such problems and produces better results at low concentration. Quercetin encapsulated chitosan conjugated NIPAAM (N-isopropyl acrylamide) nanoparticle (NQ) were synthesized via free radical mechanism and its effect was studied on brain stroke at two different concentrations [30 (NQL) and 50 (NQH) µg/kg] against the pure quercetin (Q, 30 mg/kg body weight). The nanoparticles sizes were found to be in the range of 25 – 40nm and were characterized using IR, DLS and TEM. The stroke was induced by Middle Cerebral Artery Occlusion (MCAO) rat model for 1 hour and Q and NQ were given intraparietonealy for 7 days prior to MCAO. Our results shows that NQ lowers the LPO content and improved the rats' behavior more significantly compared with pure quercetin, Q. Similar findings were observed in brain histology. Also, the NF-kB COX-2 and caspase-3 expressions were significantly lowered in NQ treated group compared with Q.
![](https://www.thieme-connect.de/media/plantamedica/201605/10-1055-s-0036-1578691-ipb43.jpg)
Fig. 1