Planta Med 2016; 82 - PB15
DOI: 10.1055/s-0036-1578663

Biological Activity Of Compounds From Dodonaea Viscosa (L.) Jacq. Var. Angustifolia

RC Forestrania 1, 2, U Munoz-Acuña 1, 2, N Freitas Fernandes 1, 2, EJ Carcache de Blanco 1, 2
  • 1Division of Pharmacy Practice and Administration
  • 2Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210

DODonaea viscosa (L.) Jacq. (Sapindaceae) is widely distributed in tropical and subtropical regions [1]. In Southern Africa, it is known as one of the most important plants in traditional therapies [2]. This study aims to isolate bioactive compounds from the stem bark of D. viscosa (L.) Jacq. var. angustifolia using MDA-MB-231 breast and PC-3 prostate cancer cell lines for bioassay-guided isolation. The stem bark of D. viscosa (L.) Jacq. var. angustifolia was extracted with MeOH and partitioned with hexane and CHCl3. The ED50 values of the hexane, CHCl3, and aqueous partition towards MDA-MB-231 were 3.8, 2.4, and 1.0 µg/mL, respectively. The CHCl3 and aqueous partitions were deemed active since the inhibition on the PC-3 was 51.6% and 55.8%. The CHCl3 and aqueous partitions of this plant also showed 97% inhibition in a PARP-1 assay. Active secondary metabolites isolated from this plant species are being identified using spectroscopic techniques such as 1D- and 2D-NMR and mass spectrometry.

References: [1] M.S. Rani, R.S. Pippalla, et al. (2009) JPRHC, 1(1):97 – 112. [2] van Heerden FR, Viljoen AM, et al. (2000) Fitoterapia, 71:602 – 604.