RSS-Feed abonnieren
DOI: 10.1055/s-0036-1571305
Do We Need Basic Research in Cardiac Surgery?
Publikationsverlauf
30. März 2015
10. September 2015
Publikationsdatum:
18. Februar 2016 (online)
![](https://www.thieme-connect.de/media/thoracic/201801/lookinside/thumbnails/10-1055-s-0036-1571305_154299r-1.jpg)
Abstract
Thinking about the daily practice of cardiac surgery, genetically altered mouse models, polymerase chain reactions, western blots, and other laboratory tools are the last that comes to mind. It is, therefore, not surprising that the pursuit of such basic science activities by practicing surgeons and those in training is often limited. However, there is an innate connection between these two seemingly different disciplines. To address and visualize this connection, we propose the following three hypotheses. First, cardiac surgery would not be at its present level of expertise without fundamental contributions of basic science. Second, without practicing cardiac surgeons performing basic research and translating their results to clinical practice next to their daily work, our ability to care for cardiac surgery patients would be poorer. Third, basic science training for those aiming to become practicing cardiac surgeons improves their ability to properly care for their patients. Finally, we will discuss some potentially even unexpected implications for our currently changing daily clinical practice.
-
References
- 1 Beckmann A, Funkat AK, Lewandowski J. , et al. Cardiac surgery in Germany during 2014: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2015; 63 (04) 258-269
- 2 Rehn L. Ueber penetrierende Herzwunden und Herznaht. Arch Klin Chir 1897; 55: 315
- 3 Gibbon Jr JH. Maintenance of cardiorespiratory functions by extracorporeal circulation. Circulation 1959; 19 (05) 646-656
- 4 Lillehei CW, Cohen M, Warden HE, Ziegler NR, Varco RL. The results of direct vision closure of ventricular septal defects in eight patients by means of controlled cross circulation. Surg Gynecol Obstet 1955; 101 (04) 446-466
- 5 Langendorff O. Untersuchungen am ueberlebenden Saeugetierherzen. Arch Ges Physiol Menschen Tiere 1895; 61: 291-332
- 6 Warburg O. The chemical constitution of respiration ferment. Science 1928; 68 (1767): 437-443
- 7 Krebs HA, Johnson WA. The role of citric acid in intermediate metabolism in animal tissues. Enzymologia 1937; 4: 148-156
- 8 Bigelow WG, Mustard WT, Evans JG. Some physiologic concepts of hypothermia and their applications to cardiac surgery. J Thorac Surg 1954; 28 (05) 463-480
- 9 Bretschneider HJ, Hübner G, Knoll D, Lohr B, Nordbeck H, Spieckermann PG. Myocardial resistance and tolerance to ischemia: physiological and biochemical basis. J Cardiovasc Surg (Torino) 1975; 16 (03) 241-260
- 10 Hearse DJ, Stewart DA, Braimbridge MV. The additive effects of potassium ions and hypothermia for the induction of elective cardiac arrest. Biochem Soc Trans 1975; 3 (03) 417-420
- 11 Weisel RD, Goldman BS, Lipton IH, Teasdale S, Mickle D, Baird RJ. Optimal myocardial protection. Surgery 1978; 84 (06) 812-821
- 12 Bull C, Cooper J, Stark J. Cardioplegic protection of the child's heart. J Thorac Cardiovasc Surg 1984; 88 (02) 287-293
- 13 Evans WN. The arterial switch operation before Jatene. Pediatr Cardiol 2009; 30 (02) 119-124
- 14 Carpentier A, Loulmet D, Carpentier A. , et al. [Open heart operation under videosurgery and minithoracotomy. First case (mitral valvuloplasty) operated with success]. C R Acad Sci III 1996; 319 (03) 219-223
- 15 von Oppell UO, Mohr FW. Chordal replacement for both minimally invasive and conventional mitral valve surgery using premeasured Gore-Tex loops. Ann Thorac Surg 2000; 70 (06) 2166-2168
- 16 Seeburger J, Borger MA, Doll N. , et al. Comparison of outcomes of minimally invasive mitral valve surgery for posterior, anterior and bileaflet prolapse. Eur J Cardiothorac Surg 2009; 36 (03) 532-538
- 17 Braunberger E, Deloche A, Berrebi A. , et al. Very long-term results (more than 20 years) of valve repair with carpentier's techniques in nonrheumatic mitral valve insufficiency. Circulation 2001; 104 (12) (Suppl. 01) I8-I11
- 18 Furnary AP, Gao G, Grunkemeier GL. , et al. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003; 125 (05) 1007-1021
- 19 Doenst T, Wijeysundera D, Karkouti K. , et al. Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 2005; 130 (04) 1144-1150
- 20 Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004; 109 (12) 1497-1502
- 21 Finfer S, Chittock DR, Su SY. , et al; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360 (13) 1283-1297
- 22 Mentzer Jr RM. Myocardial protection in heart surgery. J Cardiovasc Pharmacol Ther 2011; 16 (3–4): 290-297
- 23 Lazar HL, McDonnell M, Chipkin SR. , et al; Society of Thoracic Surgeons Blood Glucose Guideline Task Force. The Society of Thoracic Surgeons practice guideline series: Blood glucose management during adult cardiac surgery. Ann Thorac Surg 2009; 87 (02) 663-669
- 24 Faerber G, Barreto-Perreia F, Schoepe M. , et al. Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction. J Thorac Cardiovasc Surg 2011; 141 (02) 492-500 , 500.e1
- 25 Emanueli C, Angelini GD. Bridging basic science with cardiac surgery: the Bristol Heart Institute Experience. Front Surg 2015; 2: 31