RSS-Feed abonnieren
DOI: 10.1055/s-0035-1571143
Optimizing Subsequent Pregnancy Outcomes for Women with a Prior Preterm Birth
Publikationsverlauf
18. November 2015
24. November 2015
Publikationsdatum:
25. Januar 2016 (online)
Abstract
Women with a prior preterm birth are at increased risk of recurrent preterm delivery in a subsequent pregnancy. Interventions during the preconception and prenatal periods can decrease this risk. Review of the circumstances of the prior delivery can elucidate whether delivery was spontaneous or indicated, anticipate recurrence risk, and guide management in a subsequent pregnancy. Preconception interventions for women with prior preterm birth should include cessation of tobacco and substance abuse, control of underlying maternal comorbidities, and encouraging a healthy body mass index. Effective contraception, including use of long-acting reversible methods, should be encouraged to facilitate planned pregnancies with optimal interpregnancy intervals. Interventions during prenatal care include screening and treatment of infections, nutritional supplementation, and enhanced prenatal care. Women with prior spontaneous preterm birth may benefit from progesterone supplementation and serial cervical length screening, while women with prior indicated preterm birth may benefit from daily aspirin.
-
References
- 1 Damus K. Prevention of preterm birth: a renewed national priority. Curr Opin Obstet Gynecol 2008; 20 (6) 590-596
- 2 Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes. In: Behrman RE, Butler AS, ed. Preterm Birth: Causes, Consequences, and Prevention. Washington, DC: National Academies Press (US); 2007
- 3 Mercer BM, Goldenberg RL, Moawad AH , et al; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The preterm prediction study: effect of gestational age and cause of preterm birth on subsequent obstetric outcome. Am J Obstet Gynecol 1999; 181 (5, Pt 1): 1216-1221
- 4 Kazemier BM, Buijs PE, Mignini L, Limpens J, de Groot CJ, Mol BW ; EBM CONNECT. Impact of obstetric history on the risk of spontaneous preterm birth in singleton and multiple pregnancies: a systematic review. BJOG 2014; 121 (10) 1197-1208 , discussion 1209
- 5 Laughon SK, Albert PS, Leishear K, Mendola P. The NICHD Consecutive Pregnancies Study: recurrent preterm delivery by subtype. Am J Obstet Gynecol 2014; 210 (2) 131.e1-131.e8
- 6 Ananth CV, Getahun D, Peltier MR, Salihu HM, Vintzileos AM. Recurrence of spontaneous versus medically indicated preterm birth. Am J Obstet Gynecol 2006; 195 (3) 643-650
- 7 Mercer B, Milluzzi C, Collin M. Periviable birth at 20 to 26 weeks of gestation: proximate causes, previous obstetric history and recurrence risk. Am J Obstet Gynecol 2005; 193 (3, Pt 2): 1175-1180
- 8 Meis PJ, Goldenberg RL, Mercer BM , et al; Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development. The preterm prediction study: risk factors for indicated preterm births. Am J Obstet Gynecol 1998; 178 (3) 562-567
- 9 Himes KP, Simhan HN. Risk of recurrent preterm birth and placental pathology. Obstet Gynecol 2008; 112 (1) 121-126
- 10 Goldenberg RL, Andrews WW, Faye-Petersen O, Cliver S, Goepfert AR, Hauth JC. The Alabama Preterm Birth Project: placental histology in recurrent spontaneous and indicated preterm birth. Am J Obstet Gynecol 2006; 195 (3) 792-796
- 11 Shah NR, Bracken MB. A systematic review and meta-analysis of prospective studies on the association between maternal cigarette smoking and preterm delivery. Am J Obstet Gynecol 2000; 182 (2) 465-472
- 12 McCowan LME, Dekker GA, Chan E , et al; SCOPE consortium. Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study. BMJ 2009; 338: b1081-b1081
- 13 Flower A, Shawe J, Stephenson J, Doyle P. Pregnancy planning, smoking behaviour during pregnancy, and neonatal outcome: UK Millennium Cohort Study. BMC Pregnancy Childbirth 2013; 13 (1) 238
- 14 Lumley J, Chamberlain C, Dowswell T, Oliver S, Oakley L, Watson L. Interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev 2009; (3) CD001055
- 15 Patra J, Bakker R, Irving H, Jaddoe VWV, Malini S, Rehm J. Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta-analyses. BJOG 2011; 118 (12) 1411-1421
- 16 O'Leary CM, Nassar N, Kurinczuk JJ, Bower C. The effect of maternal alcohol consumption on fetal growth and preterm birth. BJOG 2009; 116 (3) 390-400
- 17 Lundsberg LS, Illuzzi JL, Belanger K, Triche EW, Bracken MB. Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study. Ann Epidemiol 2015; 25 (1) 46-54.e3
- 18 Pfinder M, Kunst AE, Feldmann R, van Eijsden M, Vrijkotte TGM. Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies. BMC Pregnancy Childbirth 2013; 13 (1) 49
- 19 Henderson J, Gray R, Brocklehurst P. Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome. BJOG 2007; 114 (3) 243-252
- 20 Janisse JJ, Bailey BA, Ager J, Sokol RJ. Alcohol, tobacco, cocaine, and marijuana use: relative contributions to preterm delivery and fetal growth restriction. Subst Abus 2014; 35 (1) 60-67
- 21 Quesada O, Gotman N, Howell HB, Funai EF, Rounsaville BJ, Yonkers KA. Prenatal hazardous substance use and adverse birth outcomes. J Matern Fetal Neonatal Med 2012; 25 (8) 1222-1227
- 22 Cleary BJ, Donnelly JM, Strawbridge JD , et al. Methadone and perinatal outcomes: a retrospective cohort study. Am J Obstet Gynecol 2011; 204 (2) 139.e1-139.e9
- 23 Almario CV, Seligman NS, Dysart KC, Berghella V, Baxter JK. Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. Am J Obstet Gynecol 2009; 201 (3) 326.e1-326.e6
- 24 Haas JS, Fuentes-Afflick E, Stewart AL , et al. Prepregnancy health status and the risk of preterm delivery. Arch Pediatr Adolesc Med 2005; 159 (1) 58-63
- 25 Smyth A, Oliveira GHM, Lahr BD, Bailey KR, Norby SM, Garovic VD. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol 2010; 5 (11) 2060-2068
- 26 Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ 2014; 348: g2301
- 27 Iams JD, Romero R, Culhane JF, Goldenberg RL. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 2008; 371 (9607) 164-175
- 28 March of Dimes, PMNCH, Save the Children, WHO. In: Howson CP, Kinney MV, Lawn JE, eds. Born Too Soon: The Global Action Report on Preterm Birth. Geneva: World Health Organization; 2012
- 29 Dunlop AL, Jack BW, Bottalico JN , et al. The clinical content of preconception care: women with chronic medical conditions. Am J Obstet Gynecol 2008; 199 (6) (Suppl. 02) S310-S327
- 30 Parker MG, Ouyang F, Pearson C , et al. Prepregnancy body mass index and risk of preterm birth: association heterogeneity by preterm subgroups. BMC Pregnancy Childbirth 2014; 14 (1) 153
- 31 Han Z, Mulla S, Beyene J, Liao G, McDonald SD ; Knowledge Synthesis Group. Maternal underweight and the risk of preterm birth and low birth weight: a systematic review and meta-analyses. Int J Epidemiol 2011; 40 (1) 65-101
- 32 McDonald SD, Han Z, Mulla S, Beyene J ; Knowledge Synthesis Group. Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ 2010; 341: c3428
- 33 Schummers L, Hutcheon JA, Bodnar LM, Lieberman E, Himes KP. Risk of adverse pregnancy outcomes by prepregnancy body mass index: a population-based study to inform prepregnancy weight loss counseling. Obstet Gynecol 2015; 125 (1) 133-143
- 34 Chan YY, Jayaprakasan K, Tan A, Thornton JG, Coomarasamy A, Raine-Fenning NJ. Reproductive outcomes in women with congenital uterine anomalies: a systematic review. Ultrasound Obstet Gynecol 2011; 38 (4) 371-382
- 35 Daly DC, Maier D, Soto-Albors C. Hysteroscopic metroplasty: six years' experience. Obstet Gynecol 1989; 73 (2) 201-205
- 36 Rechberger T, Monist M, Bartuzi A. Clinical effectiveness of Strassman operation in the treatment of bicornuate uterus. Ginekol Pol 2009; 80 (2) 88-92
- 37 Berghella V, Talucci M, Odibo A, Chen J. Mullerian anomalies: prospective follow-up with transvaginal ultrasound of the cervix. Ultrasound Obstet Gynecol 2000; 16 (Suppl. 01) 55
- 38 Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH ; Fetal Medicine Foundation Second Trimester Screening Group. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 2007; 357 (5) 462-469
- 39 Zhu B-P. Effect of interpregnancy interval on birth outcomes: findings from three recent US studies. Int J Gynaecol Obstet 2005; 89 (Suppl. 01) S25-S33
- 40 Conde-Agudelo A, Rosas-Bermúdez A, Kafury-Goeta AC. Birth spacing and risk of adverse perinatal outcomes: a meta-analysis. JAMA 2006; 295 (15) 1809-1823
- 41 Shah PS, Balkhair T, Ohlsson A, Beyene J, Scott F, Frick C. Intention to become pregnant and low birth weight and preterm birth: a systematic review. Matern Child Health J 2011; 15 (2) 205-216
- 42 Partington SN, Steber DL, Blair KA, Cisler RA. Second births to teenage mothers: risk factors for low birth weight and preterm birth. Perspect Sex Reprod Health 2009; 41 (2) 101-109
- 43 Liran D, Vardi IS, Sergienko R, Sheiner E. Adverse perinatal outcome in teenage pregnancies: is it all due to lack of prenatal care and ethnicity?. J Matern Fetal Neonatal Med 2013; 26 (5) 469-472
- 44 White K, Teal SB, Potter JE. Contraception after delivery and short interpregnancy intervals among women in the United States. Obstet Gynecol 2015; 125 (6) 1471-1477
- 45 Peipert JF, Madden T, Allsworth JE, Secura GM. Preventing unintended pregnancies by providing no-cost contraception. Obstet Gynecol 2012; 120 (6) 1291-1297
- 46 Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371 (9606) 75-84
- 47 Barros FC, Bhutta ZA, Batra M, Hansen TN, Victora CG, Rubens CE ; GAPPS Review Group. Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions. BMC Pregnancy Childbirth 2010; 10 (Suppl. 01) S3
- 48 Romero R, Oyarzun E, Mazor M, Sirtori M, Hobbins JC, Bracken M. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol 1989; 73 (4) 576-582
- 49 Smaill F, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev 2007; (2) CD000490
- 50 Clothier B, Stringer M, Jeffcoat MK. Periodontal disease and pregnancy outcomes: exposure, risk and intervention. Best Pract Res Clin Obstet Gynaecol 2007; 21 (3) 451-466
- 51 Goepfert AR, Jeffcoat MK, Andrews WW , et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004; 104 (4) 777-783
- 52 Boutin A, Demers S, Roberge S, Roy-Morency A, Chandad F, Bujold E. Treatment of periodontal disease and prevention of preterm birth: systematic review and meta-analysis. Am J Perinatol 2013; 30 (7) 537-544
- 53 Polyzos NP, Polyzos IP, Mauri D , et al. Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials. Am J Obstet Gynecol 2009; 200 (3) 225-232
- 54 Kim AJ, Lo AJ, Pullin DA, Thornton-Johnson DS, Karimbux NY. Scaling and root planing treatment for periodontitis to reduce preterm birth and low birth weight: a systematic review and meta-analysis of randomized controlled trials. J Periodontol 2012; 83 (12) 1508-1519
- 55 Johnson HL, Ghanem KG, Zenilman JM, Erbelding EJ. Sexually transmitted infections and adverse pregnancy outcomes among women attending inner city public sexually transmitted diseases clinics. Sex Transm Dis 2011; 38 (3) 167-171
- 56 Andrews WW, Goldenberg RL, Mercer B , et al. The Preterm Prediction Study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183 (3) 662-668
- 57 Rours GIJG, Duijts L, Moll HA , et al. Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study. Eur J Epidemiol 2011; 26 (6) 493-502
- 58 Rastogi S, Das B, Salhan S, Mittal A. Effect of treatment for Chlamydia trachomatis during pregnancy. Int J Gynaecol Obstet 2003; 80 (2) 129-137
- 59 Hillier SL, Nugent RP, Eschenbach DA , et al; The Vaginal Infections and Prematurity Study Group. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. N Engl J Med 1995; 333 (26) 1737-1742
- 60 Brocklehurst P, Gordon A, Heatley E, Milan SJ. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2013; 1 (1) CD000262
- 61 Odendaal HJ, Popov I, Schoeman J, Smith M, Grové D. Preterm labour—is bacterial vaginosis involved?. S Afr Med J 2002; 92 (3) 231-234
- 62 Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995; 333 (26) 1732-1736
- 63 Lamont RF, Nhan-Chang C-L, Sobel JD, Workowski K, Conde-Agudelo A, Romero R. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol 2011; 205 (3) 177-190
- 64 Bukowski R, Malone FD, Porter FT , et al. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med 2009; 6 (5) e1000061
- 65 Lassi ZS, Salam RA, Haider BA, Bhutta ZA. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Cochrane Database Syst Rev 2013; 3 (3) CD006896
- 66 Makrides M, Duley L, Olsen SF. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database Syst Rev 2006; (3) CD003402
- 67 Harper M, Thom E, Klebanoff MA , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Omega-3 fatty acid supplementation to prevent recurrent preterm birth: a randomized controlled trial. Obstet Gynecol 2010; 115 (2, Pt 1): 234-242
- 68 Bodnar LM, Platt RW, Simhan HN. Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol 2015; 125 (2) 439-447
- 69 Hofmeyr GJ, Lawrie TA, Atallah ÁN, Duley L, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6 (6) CD001059
- 70 Buppasiri P, Lumbiganon P, Thinkhamrop J, Ngamjarus C, Laopaiboon M, Medley N. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2015; 2 (2) CD007079
- 71 Hauth JC, Clifton RG, Roberts JM , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial. Obstet Gynecol 2010; 116 (3) 653-658
- 72 Polyzos NP, Mauri D, Tsappi M , et al. Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review. Obstet Gynecol Surv 2007; 62 (3) 202-206
- 73 Straub H, Qadir S, Miller G, Borders A. Stress and stress reduction. Clin Obstet Gynecol 2014; 57 (3) 579-606
- 74 Dole N, Savitz DA, Hertz-Picciotto I, Siega-Riz AM, McMahon MJ, Buekens P. Maternal stress and preterm birth. Am J Epidemiol 2003; 157 (1) 14-24
- 75 Dyson DC, Danbe KH, Bamber JA , et al. Monitoring women at risk for preterm labor. N Engl J Med 1998; 338 (1) 15-19
- 76 Collaborative Group on Preterm Birth Prevention. Multicenter randomized, controlled trial of a preterm birth prevention program. Am J Obstet Gynecol 1993; 169 (2, Pt 1): 352-366
- 77 Ickovics JR, Kershaw TS, Westdahl C , et al. Group prenatal care and perinatal outcomes: a randomized controlled trial. Obstet Gynecol 2007; 110 (2, Pt 1): 330-339
- 78 Ricketts SA, Murray EK, Schwalberg R. Reducing low birthweight by resolving risks: results from Colorado's prenatal plus program. Am J Public Health 2005; 95 (11) 1952-1957
- 79 Sosa CG, Althabe F, Belizán JM, Bergel E. Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 2015; 3 (3) CD003581
- 80 Grobman WA, Gilbert SA, Iams JD , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Activity restriction among women with a short cervix. Obstet Gynecol 2013; 121 (6) 1181-1186
- 81 McCarty-Singleton S, Sciscione AC. Maternal activity restriction in pregnancy and the prevention of preterm birth: an evidence-based review. Clin Obstet Gynecol 2014; 57 (3) 616-627
- 82 McCall CA, Grimes DA, Lyerly AD. “Therapeutic” bed rest in pregnancy: unethical and unsupported by data. Obstet Gynecol 2013; 121 (6) 1305-1308
- 83 Yost NP, Owen J, Berghella V , et al; National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network. Effect of coitus on recurrent preterm birth. Obstet Gynecol 2006; 107 (4) 793-797
- 84 Rodrigues T, Barros H. Maternal unemployment: an indicator of spontaneous preterm delivery risk. Eur J Epidemiol 2008; 23 (10) 689-693
- 85 Bonzini M, Coggon D, Palmer KT. Risk of prematurity, low birthweight and pre-eclampsia in relation to working hours and physical activities: a systematic review. Occup Environ Med 2007; 64 (4) 228-243
- 86 Saurel-Cubizolles MJ, Zeitlin J, Lelong N, Papiernik E, Di Renzo GC, Bréart G ; Europop Group. Employment, working conditions, and preterm birth: results from the Europop case-control survey. J Epidemiol Community Health 2004; 58 (5) 395-401
- 87 Meis PJ, Klebanoff M, Thom E , et al; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 2003; 348 (24) 2379-2385
- 88 Likis FE, Edwards DRV, Andrews JC , et al. Progestogens for preterm birth prevention: a systematic review and meta-analysis. Obstet Gynecol 2012; 120 (4) 897-907
- 89 Dodd JM, Jones L, Flenady V, Cincotta R, Crowther CA. Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth. Cochrane Database Syst Rev 2013; 7 (7) CD004947
- 90 How HY, Barton JR, Istwan NB, Rhea DJ, Stanziano GJ. Prophylaxis with 17 alpha-hydroxyprogesterone caproate for prevention of recurrent preterm delivery: does gestational age at initiation of treatment matter?. Am J Obstet Gynecol 2007; 197 (3) 260.e1-260.e4
- 91 Odibo AO, Stamilio DM, Macones GA, Polsky D. 17α-hydroxyprogesterone caproate for the prevention of preterm delivery: a cost-effectiveness analysis. Obstet Gynecol 2006; 108 (3, Pt 1): 492-499
- 92 Rouse DJ, Caritis SN, Peaceman AM , et al; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. N Engl J Med 2007; 357 (5) 454-461
- 93 Lim AC, Schuit E, Bloemenkamp K , et al. 17α-hydroxyprogesterone caproate for the prevention of adverse neonatal outcome in multiple pregnancies: a randomized controlled trial. Obstet Gynecol 2011; 118 (3) 513-520
- 94 Schaaf JM, Hof MHP, Mol BWJ, Abu-Hanna A, Ravelli ACJ. Recurrence risk of preterm birth in subsequent singleton pregnancy after preterm twin delivery. Am J Obstet Gynecol 2012; 207 (4) 279.e1-279.e7
- 95 Taipale P, Hiilesmaa V. Sonographic measurement of uterine cervix at 18-22 weeks' gestation and the risk of preterm delivery. Obstet Gynecol 1998; 92 (6) 902-907
- 96 Iams JD, Goldenberg RL, Meis PJ , et al; National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. The length of the cervix and the risk of spontaneous premature delivery. N Engl J Med 1996; 334 (9) 567-572
- 97 Owen J, Hankins G, Iams JD , et al. Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol 2009; 201 (4) 375.e1-375.e8
- 98 Berghella V, Rafael TJ, Szychowski JM, Rust OA, Owen J. Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: a meta-analysis. Obstet Gynecol 2011; 117 (3) 663-671
- 99 Saccone G, Rust O, Althuisius S, Roman A, Berghella V. Cerclage for short cervix in twin pregnancies: systematic review and meta-analysis of randomized trials using individual patient-level data. Acta Obstet Gynecol Scand 2015; 94 (4) 352-358
- 100 Berghella V, Mackeen AD. Cervical length screening with ultrasound-indicated cerclage compared with history-indicated cerclage for prevention of preterm birth: a meta-analysis. Obstet Gynecol 2011; 118 (1) 148-155
- 101 Rush RW, Isaacs S, McPherson K, Jones L, Chalmers I, Grant A. A randomized controlled trial of cervical cerclage in women at high risk of spontaneous preterm delivery. Br J Obstet Gynaecol 1984; 91 (8) 724-730
- 102 Lazar P, Gueguen S, Dreyfus J, Renaud R, Pontonnier G, Papiernik E. Multicentred controlled trial of cervical cerclage in women at moderate risk of preterm delivery. Br J Obstet Gynaecol 1984; 91 (8) 731-735
- 103 MRC/RCOG Working Party on Cervical Cerclage. Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists multicentre randomised trial of cervical cerclage. Br J Obstet Gynaecol 1993; 100 (6) 516-523
- 104 Barton JR, Sibai BM. Prediction and prevention of recurrent preeclampsia. Obstet Gynecol 2008; 112 (2, Pt 1): 359-372
- 105 Roberge S, Villa P, Nicolaides K , et al. Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Fetal Diagn Ther 2012; 31 (3) 141-146
- 106 Roberge S, Giguère Y, Villa P , et al. Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis. Am J Perinatol 2014; 31 (6) e3
- 107 LeFevre ML ; U.S. Preventive Services Task Force. Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2014; 161 (11) 819-826