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Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2016; 35(01): 039-044
DOI: 10.1055/s-0035-1570498
Review Article | Artigo de Revisão
Thieme Publicações Ltda Rio de Janeiro, Brazil

Aspectos neurofuncionais do cerebelo: o fim de um dogma

Neurofunctional Aspects of Cerebellum: The End of a Dogma
Daniel Damiani
1   Médico, Biomédico, Professor, Pós-Graduação de Neurociências, Universidade Anhembi-Morumbi, São Paulo, SP, Brasil
,
Vanessa Pires Gonçalves
2   Monitora, Pós-Graduação em Neurociências, Universidade Anhembi Morumbi, São Paulo, SP, Brasil
,
Letícia Kuhl
2   Monitora, Pós-Graduação em Neurociências, Universidade Anhembi Morumbi, São Paulo, SP, Brasil
,
Poliana Helena Aloi
3   Estudante, Pós-Graduação em Neurociências, Universidade Anhembi-Morumbi, São Paulo, SP, Brasil
,
Anna Maria Nascimento
4   Coordenadora Geral, Pós-Graduação em Neurociências, Universidade Anhembi-Morumbi, São Paulo, SP, Brasil
› Author Affiliations
Further Information

Publication History

09 March 2015

28 August 2015

Publication Date:
13 January 2016 (online)

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Resumo

Há séculos o cerebelo é considerado uma estrutura do sistema nervoso central responsável exclusivamente pela coordenação do movimento, fazendo diversas conexões com as áreas motoras e associativas do córtex cerebral. No entanto, nos últimos anos, avanços em neuroimagem funcional têm atribuído ao cerebelo funções cognitivo-afetivas, identificando-as anatômica e funcionalmente. Nesta revisão, os autores trazem as mais recentes informações sobre as funções cerebelares, considerando a síndrome cognitivo-afetiva correlacionada ao cerebelo e pondo fim a mais um dogma das neurociências.

Abstract

For centuries the cerebellum is considered a structure of the central nervous system solely responsible for coordination of the movement, making several connections with the motor areas and associations areas of the cerebral cortex. However, in recent years, advances in functional neuroimaging has assigned the cerebellum cognitive-affective functions, identifying the anatomy and functionally pathways. In this review, the authors come with the latest information about the cerebellar functions, whereas the syndrome cerebellar cognitive-affective, it correlated, putting an end to more a dogma in neuroscience.

Palavras-Chave

cerebelo - síndrome cognitivo-afetiva - neurofisiologia cerebelar - cognição cerebelar

Keywords

cerebellum - cognitive-affective syndrome - cerebellar neurofunctions - cognitive cerebellum
 

  • Referências

  • 1 Bandeira F, Lent R, Herculano-Houzel S. Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat. Proc Natl Acad Sci U S A 2009; 106 (33) 14108-14113
    CrossrefPubMedGoogle Scholar
  • 2 Barlow JS. The Cerebellum and Adaptive Control. Cambridge: Cambridge University Press; , page 3–5, 2002. http://books.google.com.br/books
    CrossrefGoogle Scholar
  • 3 Chudler EH. Milestones in Neuroscience Research. http://faculty.washington.edu/chudler/hist.html (acessado em 2009)
    PubMedGoogle Scholar
  • 4 Schmahmann JD, Caplan D. Cognition, emotion and the cerebellum. Brain 2006; 129 (Pt 2): 290-292
    PubMedGoogle Scholar
  • 5 Ito M. Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci 2008; 9 (4) 304-313
    CrossrefPubMedGoogle Scholar
  • 6 Schmahmann JD, Pandya DN, Wang R , et al. Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain 2007; 130 (Pt 3): 630-653
    CrossrefPubMedGoogle Scholar
  • 7 Manto M, Mariën P. Schmahmann's syndrome - identification of the third cornerstone of clinical ataxiology. Cerebellum Ataxias 2015; 2 (2) 2
    CrossrefPubMedGoogle Scholar
  • 8 Bostan AC, Dum RP, Strick PL. The basal ganglia communicate with the cerebellum. Proc Natl Acad Sci U S A 2010; 107 (18) 8452-8456
    CrossrefPubMedGoogle Scholar
  • 9 D'Angelo E, Casali S. Seeking a Unified Framework for Cerebellar Function and Dysfunction: from circuit operations to cognition. Front Neural Circuits 2012; 6 (116) 1-23
    PubMedGoogle Scholar
  • 10 Blumenfeld H. Neuroanatomy through Clinical Case. Second Edition. 2010. . Sinauer Associate, Yale University School of Medicine
    Google Scholar
  • 11 Kandel ER, Schwartz JH, Jessel TM. Principles of Neural Sciente (4th Edition). New York: McGraw-Hill; 2000
    Google Scholar
  • 12 Voogd J. Cerebellar zones: a personal history. Cerebellum 2011; 10 (3) 334-350
    CrossrefPubMedGoogle Scholar
  • 13 Voogd J. The human cerebellum. J Chem Neuroanat 2003; 26 (4) 243-252
    CrossrefPubMedGoogle Scholar
  • 14 Lechtenberg R, Gilman S. Speech disorders in cerebellar disease. Ann Neurol 1978; 3 (4) 285-290
    CrossrefPubMedGoogle Scholar
  • 15 Schutter DJLG, van Honk J. The cerebellum on the rise in human emotion. Cerebellum 2005; 4 (4) 290-294
    CrossrefPubMedGoogle Scholar
  • 16 Riby DM, Hancock PJB. Viewing it differently: social scene perception in Williams syndrome and autism. Neuropsychologia 2008; 46 (11) 2855-2860
    CrossrefPubMedGoogle Scholar
  • 17 Schmahmann JD, Smith EE, Eichler FS, Filley CM. Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates. Ann N Y Acad Sci 2008; 1142: 266-309
    CrossrefPubMedGoogle Scholar
  • 18 Mariën P, Beaton A. The enigmatic linguistic cerebellum: clinical relevance and unanswered questions on nonmotor speech and language deficits in cerebellar disorders. Cerebellum Ataxias 2014; 1: 12
    CrossrefPubMedGoogle Scholar
  • 19 Mariën P, Ackermann H, Adamaszek M , et al. Consensus paper: Language and the cerebellum: an ongoing enigma. Cerebellum 2014; 13 (3) 386-410
    PubMedGoogle Scholar
  • 20 Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 2010; 46 (7) 831-844
    CrossrefPubMedGoogle Scholar
  • 21 Mariën P, Saerens J, Nanhoe R , et al. Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings. J Neurol Sci 1996; 144 (1–2) 34-43
    CrossrefPubMedGoogle Scholar
  • 22 Engelhardt E, Moreira DM. O cerebelo e suas principais conexões: estudo com tensor de difusão. Rev Bras Neurol 2009; 45 (3) 17-27
    PubMedGoogle Scholar
  • 23 Schmahmann JD, Doyon J, McDonald D , et al. Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space. Neuroimage 1999; 10 (3 Pt 1): 233-260
    CrossrefPubMedGoogle Scholar
  • 24 Tiemeier H, Lenroot RK, Greenstein DK, Tran L, Pierson R, Giedd JN. Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage 2010; 49 (1) 63-70
    CrossrefPubMedGoogle Scholar
  • 25 Manni E, Petrosini L. A century of cerebellar somatotopy: a debated representation. Nat Rev Neurosci 2004; 5 (3) 241-249
    PubMedGoogle Scholar