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Semin Liver Dis 2015; 35(04): 402-420
DOI: 10.1055/s-0035-1567830
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Genome-Wide Association Studies and Hepatitis C: Harvesting the Benefits of the Genomic Revolution

Mohammed Eslam
1   Storr Liver Centre, Westmead Millennium Institute, Westmead Hospital and University of Sydney, New South Wales, Australia
,
Jacob George
1   Storr Liver Centre, Westmead Millennium Institute, Westmead Hospital and University of Sydney, New South Wales, Australia
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Publication History

Publication Date:
16 December 2015 (online)

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Abstract

Utilizing genome-wide association studies (GWASs) to examine the variation in hepatitis C virus (HCV) phenotypes has led to quantum improvements in our understanding of both the genetic basis and the underlying pathogenesis of HCV infection. In this context, the discovery of interferon lambda polymorphisms is unique with far reaching implications that extend well beyond HCV to various other liver and extrahepatic diseases. In this review, we summarize the data on the impact of GWASs on our understanding of HCV disease.

Keywords

genome-wide association studies - hepatitis C virus