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J Pediatr Genet 2015; 04(03): 136-143
DOI: 10.1055/s-0035-1564440
DOI: 10.1055/s-0035-1564440
Review Article
Overgrowth Syndromes
Weitere Informationen
Publikationsverlauf
15. Mai 2015
20. Mai 2015
Publikationsdatum:
25. September 2015 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029027/201503/lookinside/thumbnails/10-1055-s-0035-1564440_1503-1.jpg)
Abstract
Numerous multiple malformation syndromes associated with pathologic overgrowth have been described and, for many, their molecular bases elucidated. This review describes the characteristic features of these overgrowth syndromes, as well as the current understanding of their molecular bases, intellectual outcomes, and cancer predispositions. We review syndromes such as Sotos, Malan, Marshall–Smith, Weaver, Simpson–Golabi–Behmel, Perlman, Bannayan–Riley–Ruvalcaba, PI3K-related, Proteus, Beckwith–Wiedemann, fibrous dysplasia, Klippel–Trenaunay–Weber, and Maffucci.
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