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Synthesis 2016; 48(19): 3413-3419
DOI: 10.1055/s-0035-1562785
DOI: 10.1055/s-0035-1562785
paper
Highly Diastereoselective and Irreversible Aldol Reactions of N-Sulfonylimidates
Weitere Informationen
Publikationsverlauf
Received: 26. Mai 2016
Accepted after revision: 29. Juni 2016
Publikationsdatum:
30. August 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201619/lookinside/thumbnails/ss-2016-c0384-op_10-1055_s-0035-1562785-1.jpg)
Dedicated to the memory of Prof. Jean Normant, an exceptional and inspiring supervisor
Abstract
A mild method for the aldolization of N-sulfonylimidates was developed. The reaction proceeds in excellent diastereoselectivity to provide a range of useful β-hydroxyimidates in high yield. The innate reversibility of the reaction is suppressed by the use of a titanium complex as a Lewis acid.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562785.
- Supporting Information
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