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Synthesis 2016; 48(23): 4131-4142
DOI: 10.1055/s-0035-1562613
DOI: 10.1055/s-0035-1562613
paper
Intramolecular Mizoroki–Heck Reaction of 2-Thiosubstituted Acrylates for the Synthesis of 3-Substituted Benzo[b]thiophene-2-carboxylates
Further Information
Publication History
Received: 16 June 2016
Accepted after revision: 11 July 2016
Publication Date:
23 August 2016 (online)
Abstract
3-Substituted 2-(phenylthio)acrylates prepared from aldol condensation using titanium tetrachloride were employed to synthesize benzo[b]thiophenes. The acrylates containing aryls and alkyls generated the desired benzo[b]thiophenes in reasonable yields under the optimized Heck condition, but acrylates having heteroaryls gave the desired products in poor yields or no products under the condition.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562613.
- Supporting Information
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