Synlett 2016; 27(15): 2241-2245
DOI: 10.1055/s-0035-1562135
letter
© Georg Thieme Verlag Stuttgart · New York

Transition-Metal-Free Acylation of Quinolines and Isoquinolines with Arylmethanols via Oxidative Cross-Dehydrogenative Coupling Reactions

Mehdi Adib*
a   School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran   eMail: madib@khayam.ut.ac.ir
,
Rahim Pashazadeh
a   School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran   eMail: madib@khayam.ut.ac.ir
,
Saideh Rajai-Daryasarei
a   School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran   eMail: madib@khayam.ut.ac.ir
,
Roya Kabiri
b   NMR Lab, Faculty of Chemistry, Tabriz University, Tabriz, Iran
,
Seyed Jamal Addin Gohari
c   Department of Chemistry, Imam Hossein University, Tehran, Iran
› Institutsangaben
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Publikationsverlauf

Received: 26. Januar 2016

Accepted after revision: 10. April 2016

Publikationsdatum:
18. Mai 2016 (online)


Abstract

An efficient acylation of quinolines and isoquinolines is described by use of arylmethanols as the acylating agents through a C–C bond formation via an oxidative cross-dehydrogenative coupling (CDC) strategy. This C-aroylation reaction was carried out by use of K2S2O8 as oxidant and methyltrioctylammonium chloride (Aliquat 336) as a transfer agent in MeCN at 80 °C under transition-metal-free conditions.

Supporting Information