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Synthesis 2016; 48(14): 2245-2254
DOI: 10.1055/s-0035-1561598
DOI: 10.1055/s-0035-1561598
paper
Synthesis of Novel 3,19-Dihydroxyjolkinolides and Related Derivatives Starting from Andrographolide
Weitere Informationen
Publikationsverlauf
Received: 20. Januar 2016
Accepted after revision: 07. März 2016
Publikationsdatum:
03. Mai 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201614/lookinside/thumbnails/ss-2016-f0049-op_10-1055_s-0035-1561598-1.jpg)
Abstract
The jolkinolides are a series of naturally occurring ent-abietane diterpenes with potent antitumor activity, which have been isolated from the genus Euphorbia. We describe the first method for the total synthesis of 3,19-dihydroxyjolkinolide and its derivatives. The strategy for the synthesis of 3,19-dihydroxyjolkinolide A has 12 steps with an overall yield of 4.3%. The synthesized compounds were evaluated for their antitumor activity in nine kinds of tumor cell lines.
Key words
ent-abietane diterpenes - jolkinolides - andrographolide - Wittig–Horner reaction - antitumor evaluationSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561598.
- Supporting Information
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