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Synthesis 2016; 48(21): 3812-3820
DOI: 10.1055/s-0035-1561463
DOI: 10.1055/s-0035-1561463
paper
Stereoselective Synthesis of the Revised Structure of γ-Lactone Polyketide from Diaporthe sp. SXZ-19 and Its C-8 Epimer
Further Information
Publication History
Received: 16 March 2016
Accepted after revision: 29 April 2016
Publication Date:
15 June 2016 (online)
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Abstract
Revised structure of γ-lactone polyketide from Diaporthe sp. SXZ-19 and its C8-epimer were synthesized from TBS protected (S)-lactaldehyde and 2,3-O-cyclohexylidene-d-glyceraldehyde, which was derived from d-mannitol. The target γ-lactones were prepared via a common alkyne intermediate utilizing alkyne-aldehyde coupling reactions by changing the reaction conditions. In addition, Carreira and Ohira–Bestmann reactions were used as key steps to achieve the targets.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561463.
- Supporting Information
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