Synthesis of Novel 3-Acetyl-2-aminothiophenes and Investigation of their Behaviour in the Reaction with Vilsmeier–Haack Reagent

Abstract

Through an investigation into the behaviour of 3-acetyl-2-aminothiophene in the reaction with Vilsmeier–Haack reagent, an efficient method for the synthesis of 4-chlorothieno[2,3-b]pyridine derivatives has been established. Gewald’s classical synthesis starting from cyanoacetone, ketones and elemental sulphur has been applied to produce the starting materials.

Key words

Vilsmeier–Haack - Gewald’s reaction - thieno[2,3-b]pyridine - Buchwald–Hartwig - cross coupling

• References

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