The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

Abstract

A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.

Key words

Ugi reaction - Passerini reaction - propiolic acid - ethyl glyoxylate - pyrrolone - butenolide

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• 1 These authors contributed equally to this work.
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