Two Novel and Simple Approaches to ‘CD45 Protein Tyrosine Phosphatase Inhibitor’ (Z)-Pulchellalactam and Derivatives

Abstract

Two novel routes to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, and its derivatives are reported in two steps starting from dienoic acids through electrophilic cyclisation. This methodology proceeds regio- and stereoselectively, and can be used to design a library of synthetic pulchellalactam analogues.

Key words

dienoic acids - dienamides - iodocyclization - electrophilic cyclization - pulchellalactam

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