Synthesis 2016; 48(04): 493-503
DOI: 10.1055/s-0035-1560556
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Progress in Palladium-Catalyzed Asymmetric Hydrophos­phination

Sumod A. Pullarkat*
Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore   Email: sumod@ntu.edu.sg
› Author Affiliations
Further Information

Publication History

Received: 28 October 2015

Accepted after revision: 24 November 2015

Publication Date:
29 December 2015 (online)


Abstract

Asymmetric construction of P–C bonds is considered to be one of the most powerful methods for the preparation of chiral organophosphorus compounds. This review highlights recent progress in palladium-catalyzed asymmetric hydrophosphination reactions involving activated C=C bonds and diarylphosphines. The main catalytic systems employed for this protocol together with current substrate scope and mechanistic insights are described.

1 Introduction

2 Five-Membered CN/CP Palladacycle Catalyzed Protocols

3 PCP Pincer-Type Catalyst Based Protocols

4 NCN and PCN Pincers as Catalysts

5 Conclusion and Outlook

 
  • References


    • For selected examples, see:
    • 1a Lühr S, Holz J, Börner A. ChemCatChem 2011; 3: 1708
    • 1b Rauchfuss T. Functionalized Tertiary Phosphines and Related Ligands in Organometallic Coordination Chemistry and Catalysis. In Homogeneous Catalysis with Metal Phosphine Complexes. Pignolet L. Springer; New York: 1983: 239-256
    • 1c Kamer PC. J, van Leeuwen PW. N. M. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis. Wiley; Chichester: 2012
    • 1d Imamoto T. J. Synth. Org. Chem., Jpn. 2007; 65: 1060
    • 1e Hayashi T. Acc. Chem. Res. 2000; 33: 354
  • 3 Kovacik I, Wicht DK, Grewal NS, Glueck DS, Incarvito CD, Guzei IA, Rheingold AL. Organometallics 2000; 19: 950
  • 4 Scriban C, Kovacik I, Glueck DS. Organometallics 2005; 24: 4871
    • 5a Sadow AD, Haller I, Fadini L, Togni A. J. Am. Chem. Soc. 2004; 126: 14704
    • 5b Sadow AD, Togni A. J. Am. Chem. Soc. 2005; 127: 17012
    • 6a Bartoli G, Bosco M, Carlone A, Locatelli M, Mazzanti A, Sambri L, Melchiorre P. Chem. Commun. 2007; 722
    • 6b Carlone A, Bartoli G, Bosco M, Sambri L, Melchiorre P. Angew. Chem. Int. Ed. 2007; 46: 4504
    • 6c Ibrahem I, Rios R, Vesely J, Hammar P, Eriksson L, Himo F, Cordova A. Angew. Chem. Int. Ed. 2007; 46: 4507
    • 6d Ibrahem I, Hammar P, Vesely J, Rios R, Eriksson L, Cordova A. Adv. Synth. Catal. 2008; 350: 1875
  • 7 Enders D, Saint-Dizier A, Lannou M.-I, Lenzen A. Eur. J. Org. Chem. 2006; 29
    • 8a Leung P.-H. Acc. Chem. Res. 2004; 37: 169
    • 8b Ma M, Pullarkat SA, Li Y, Leung P.-H. Inorg. Chem. 2007; 46: 9488
    • 8c Ma M, Pullarkat SA, Yuan M, Zhang N, Li Y, Leung P.-H. Organometallics 2009; 28: 4886
    • 8d Ma M, Pullarkat SA, Li Y, Leung P.-H. Eur. J. Inorg. Chem. 2010; 1865
    • 8e Ma M, Zhang N, Li Y, Pullarkat SA, Leung P.-H. Organometallics 2015; 34: 5081
  • 9 Pullarkat S, Leung P.-H. Top. Organomet. Chem. 2013; 43: 145
  • 10 Huang Y, Pullarkat SA, Li Y, Leung P.-H. Chem. Commun. 2010; 46: 6950
  • 11 Huang Y, Pullarkat SA, Li Y, Leung P.-H. Inorg. Chem. 2012; 51: 2533
  • 12 Jia Y.-X, Li B.-B, Li Y, Pullarkat SA, Xu K, Hirao H, Leung P.-H. Organometallics 2014; 33: 6053
  • 13 Sabater S, Mata JA, Peris E. Organometallics 2013; 32: 1112
  • 14 Huang Y, Pullarkat SA, Teong S, Chew RJ, Li Y, Leung P.-H. Organometallics 2012; 31: 4871
  • 15 Huang Y, Chew RJ, Li Y, Pullarkat SA, Leung P.-H. Org. Lett. 2011; 13: 5862
  • 16 Yang X.-Y, Tay WS, Li Y, Pullarkat SA, Leung P.-H. Organometallics 2015; 34: 1582
  • 17 Chew RJ, Teo KY, Huang Y, Li B.-B, Li Y, Pullarkat SA, Leung P.-H. Chem. Commun. 2014; 50: 8768
  • 18 Chew RJ, Lu Y, Jia Y.-X, Li B.-B, Wong EH. Y, Goh R, Li Y, Huang Y, Pullarkat SA, Leung P.-H. Chem. Eur. J. 2014; 20: 14514
  • 19 Gan K, Sadeer A, Xu C, Li Y, Pullarkat SA. Organometallics 2014; 33: 5074
  • 20 Chew RJ, Li X.-R, Li Y, Pullarkat SA, Leung P.-H. Chem. Eur. J. 2015; 21: 4800
    • 21a Arseniyadis S, Valleix A, Wagner A, Mioskowski C. Angew. Chem. Int. Ed. 2004; 43: 3314
    • 21b Trost BM, Toste FD. J. Am. Chem. Soc. 1999; 121: 4545
  • 22 Swain CG, Swain MS, Powell AL, Alunni S. J. Am. Chem. Soc. 1983; 105: 502
  • 23 Bürgi HB, Dunitz JD, Lehn JM, Wipff G. Tetrahedron 1974; 30: 1563
  • 24 Chew RJ, Sepp K, Li B.-B, Li Y, Zhu P.-C, Tan NS, Leung P.-H. Adv. Synth. Catal. 2015; 357: 3297
  • 25 Xu C, Jun Hao Kennard G, Hennersdorf F, Li Y, Pullarkat SA, Leung P.-H. Organometallics 2012; 31: 3022
  • 26 Huang Y, Chew RJ, Pullarkat SA, Li Y, Leung P.-H. J. Org. Chem. 2012; 77: 6849
  • 27 Chew RJ, Huang Y, Li Y, Pullarkat SA, Leung P.-H. Adv. Synth. Catal. 2013; 355: 1403
  • 28 Chooi SY. M, Siah SY, Leung PH, Mok KF. Inorg. Chem. 1993; 32: 4812
  • 29 Feng J.-J, Chen X.-F, Shi M, Duan W.-L. J. Am. Chem. Soc. 2010; 132: 5562
  • 30 Du D, Duan W.-L. Chem. Commun. 2011; 47: 11101
  • 31 Huang M, Li C, Huang J, Duan W.-L, Xu S. Chem. Commun. 2012; 48: 11148
  • 32 Cho B, Tan C.-H, Wong MW. Org. Biomol. Chem. 2011; 9: 4550
  • 33 Feng J.-J, Huang M, Lin Z.-Q, Duan W.-L. Adv. Synth. Catal. 2012; 354: 3122
  • 34 Ding B, Zhang Z, Xu Y, Liu Y, Sugiya M, Imamoto T, Zhang W. Org. Lett. 2013; 15: 5476
  • 35 Xu Y, Yang Z, Ding B, Liu D, Liu Y, Sugiya M, Imamoto T, Zhang W. Tetrahedron 2015; 71: 6832
  • 36 Du D, Lin Z.-Q, Lu J.-Z, Li C, Duan W.-L. Asian J. Org. Chem. 2013; 2: 392
  • 37 Lu J, Ye J, Duan W.-L. Org. Lett. 2013; 15: 5016
  • 38 Lu J, Ye J, Duan W.-L. Chem. Commun. 2014; 50: 698
  • 39 Yang X.-Y, Gan JH, Li Y, Pullarkat SA, Leung P.-H. Dalton Trans. 2015; 44: 1258
  • 40 Yang X.-Y, Tay WS, Li Y, Pullarkat SA, Leung P.-H. Organometallics 2015; 34: 5196
  • 41 Jia Y.-X, Yang X.-Y, Tay WS, Li Y, Pullarkat SA, Xu K, Hirao H, Leung P.-H. Dalton Trans. 2016; 45 DOI: 10.1039/C5DT02049B
  • 42 Li C, Bian Q.-L, Xu S, Duan W.-L. Org. Chem. Front. 2014; 1: 541
  • 43 Hao X.-Q, Zhao Y.-W, Yang J.-J, Niu J.-L, Gong J.-F, Song M.-P. Organometallics 2014; 33: 1801
  • 44 Hao XQ, Huang JJ, Wang T, Lv J, Gong JF, Song MP. J. Org. Chem. 2014; 79: 9512