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Synlett 2015; 26(19): 2697-2701
DOI: 10.1055/s-0035-1560537
DOI: 10.1055/s-0035-1560537
letter
Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks
Weitere Informationen
Publikationsverlauf
Received: 30. Juli 2015
Accepted after revision: 02. November 2015
Publikationsdatum:
06. November 2015 (online)
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Abstract
We report a new and rapid method for side-chain dehydration/dehydrothiolation of serine, threonine, and cysteine building blocks. The method relies on activation with 3-nitro-2-pyridinesulfenyl chloride (Npys-Cl) followed by treatment with base. It is possible to perform the sequence as a one-pot operation and due to the significant functional-group compatibility of Npys-Cl, this method may be compatible with multifunctional and complex substrates.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560537.
- Supporting Information
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References and Notes
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