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Synlett 2015; 26(19): 2720-2723
DOI: 10.1055/s-0035-1560491
DOI: 10.1055/s-0035-1560491
letter
Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB
Further Information
Publication History
Received: 29 July 2015
Accepted after revision: 15 September 2015
Publication Date:
09 October 2015 (online)
![](https://www.thieme-connect.de/media/synlett/201519/lookinside/thumbnails/st-2015-r0588-l_10-1055_s-0035-1560491-1.jpg)
Abstract
We describe the synthesis of a variety of new alkylated mononucleotides and examine their repair proficiency with the prokaryotic direct DNA repair protein AlkB. A comparison of rates of repair among the different substrates supports the currently accepted radical mechanism.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560491.
- Supporting Information
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References and Notes
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