Synlett 2015; 26(19): 2714-2719
DOI: 10.1055/s-0035-1560209
letter
© Georg Thieme Verlag Stuttgart · New York

Rapid and Efficient Microwave-Assisted Hydrophosphinylation of Unactivated Alkenes with H-Phosphinic Acids without Added Metal or Radical Initiator

Panagiota Troupa
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15701 Athens, Greece   eMail: svassiliou@chem.uoa.gr
,
Georgia Katsiouleri
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15701 Athens, Greece   eMail: svassiliou@chem.uoa.gr
,
Stamatia Vassiliou*
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15701 Athens, Greece   eMail: svassiliou@chem.uoa.gr
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Publikationsverlauf

Received: 22. Juli 2015

Accepted after revision: 09. August 2015

Publikationsdatum:
01. September 2015 (online)


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Abstract

A microwave-assisted hydrophosphinylation of unactivated alkenes with phosphinic acid and its derivatives under metal-free and initiator-free conditions is reported. Such hydrophosphinylations are operationally simple, use aqueous hypophosphorus acid, H-phenylphosphinic acid, and H-alkylphosphinic acids, and seem to proceed by a radical mechanism. Good isolated yields were obtained using a reasonable excess of the appropriate reagent.

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