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Synlett 2015; 26(18): 2557-2560
DOI: 10.1055/s-0035-1560180
DOI: 10.1055/s-0035-1560180
letter
MnO2-Catalyzed Oxidative Alkylation of Enamides with Ethers via C(sp3)–H/C(sp2)–H Cross-Dehydrogenative Coupling and Hydrolysis Sequence
Weitere Informationen
Publikationsverlauf
Received: 25. Mai 2015
Accepted after revision: 23. Juli 2015
Publikationsdatum:
02. September 2015 (online)
![](https://www.thieme-connect.de/media/synlett/201518/lookinside/thumbnails/st-2015-w0396-l_10-1055_s-0035-1560180-1.jpg)
Abstract
A new MnO2-catalyzed oxidative alkylation of enamides with a C(sp3)–H bond adjacent to an oxygen atom is described. This method achieves a C(sp3)-H/C(sp2)-H cross-dehydrogenative coupling and hydrolysis, thus providing efficient and general access to a variety of β-oxo ketones.
Key words
C(sp3)–H/C(sp2)–H cross-dehydrogenative coupling - ethers - enamides - β-oxo ketones - radicalsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560180.
- Supporting Information
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For reviews on C–H functionalization, see:
For some representative examples, see:
For reviews, see: