Synthesis 2015; 47(23): 3727-3732
DOI: 10.1055/s-0035-1560177
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Imidazo[1,2-f]phenanthridines through Palladium-Catalyzed Intramolecular C–C Bond Formation

Hitesh Kumar Saini
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India   eMail: anilkumar@pilani.bits-pilani.ac.in
,
Shiv Dhiman
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India   eMail: anilkumar@pilani.bits-pilani.ac.in
,
Kasiviswanadharaju Pericherla
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India   eMail: anilkumar@pilani.bits-pilani.ac.in
,
Anil Kumar*
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India   eMail: anilkumar@pilani.bits-pilani.ac.in
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Weitere Informationen

Publikationsverlauf

Received: 25. Mai 2015

Accepted after revision: 27. Juli 2015

Publikationsdatum:
28. August 2015 (online)


Abstract

A simple and convenient approach is developed for the synthesis of the imidazo[1,2-f]phenanthridine framework via post-functionalization of imidazoles obtained through four-component reactions of 1,2-dicarbonyl compounds, anilines, aldehydes and ammonium acetate. The methodology involves palladium-catalyzed direct arylation through sp2 C–H activation. The reported procedure delivers good to high yields of imidazo[1,2-f]phenanthridine derivatives (58–94%) starting from readily available precursors.

Supporting Information

 
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