Synlett 2015; 26(20): 2751-2762
DOI: 10.1055/s-0035-1560169
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© Georg Thieme Verlag Stuttgart · New York

Recent Progress in the Development of Multitasking Directing Groups for Carbon–Hydrogen Activation Reactions

Huan Sun
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen 518055, P. R. of China   Email: huangyong@pkusz.edu.cn
,
Yong Huang*
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen 518055, P. R. of China   Email: huangyong@pkusz.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 17 May 2015

Accepted after revision: 15 July 2015

Publication Date:
07 September 2015 (online)


Abstract

Selective carbon–hydrogen activation reactions can be accomplished in a predictive manner using directing auxiliaries. However, the majority of directing groups discovered to date are difficult to remove or to transform into a desirable functionality. Recently, removable, cleavable, and redox-neutral directing groups have been developed that significantly broaden both the substrate scope and synthetic diversity of carbon–hydrogen functionalization reactions. In this short account, we summarize recent progress we have made in the development of multitasking (removable, cleavable, redox-neutral, manipulable) directing groups for carbon–hydrogen activation reactions.

1 Introduction

2 Triazene

3 Nitrous Amide

4 Pyrazolidinone

5 N-Oxyacetamide

6 Conclusion

 
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