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DOI: 10.1055/s-0035-1560169
Recent Progress in the Development of Multitasking Directing Groups for Carbon–Hydrogen Activation Reactions
Publication History
Received: 17 May 2015
Accepted after revision: 15 July 2015
Publication Date:
07 September 2015 (online)
Abstract
Selective carbon–hydrogen activation reactions can be accomplished in a predictive manner using directing auxiliaries. However, the majority of directing groups discovered to date are difficult to remove or to transform into a desirable functionality. Recently, removable, cleavable, and redox-neutral directing groups have been developed that significantly broaden both the substrate scope and synthetic diversity of carbon–hydrogen functionalization reactions. In this short account, we summarize recent progress we have made in the development of multitasking (removable, cleavable, redox-neutral, manipulable) directing groups for carbon–hydrogen activation reactions.
1 Introduction
2 Triazene
3 Nitrous Amide
4 Pyrazolidinone
5 N-Oxyacetamide
6 Conclusion
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For recent reviews on carbon-hydrogen activation, see:
For reviews on transition-metal-catalyzed cross-couplings, see:
For reviews of various directing groups, see:
For a review on heterocyclization reactions, see:
For selected examples of heterocyclization reactions, see:
For recent reviews of removable DGs, see:
For reviews on indole synthesis, see:
For the synthesis of N-protected indoles using directed C-H activation reactions, see:
For recent reviews on redox-neutral C-H activation, see:
For selected examples of redox-neutral C-H activation reactions via nitrogen-oxygen bond cleavage, see:
For recent reviews on ruthenium-catalyzed carbon-hydrogen activation reactions, see: