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Synlett 2015; 26(16): 2277-2279
DOI: 10.1055/s-0035-1560066
DOI: 10.1055/s-0035-1560066
letter
Highly Stereoselective Synthesis of Isoindole Derivatives Containing an Azetidinone Ring
Weitere Informationen
Publikationsverlauf
Received: 19. Mai 2015
Accepted after revision: 03. Juli 2015
Publikationsdatum:
01. September 2015 (online)
![](https://www.thieme-connect.de/media/synlett/201516/lookinside/thumbnails/st-2015-d0387-l_10-1055_s-0035-1560066-1.jpg)
Abstract
Isoindole derivatives containing an azetidin-2-one moiety were prepared from phthalic anhydride by an approach that involves a [2π+2π] cycloaddition of an imine to a novel ketene generated in situ, and an electrocyclic reaction of a zwitterionic intermediate. The reactions were highly stereoselective and trans-β-lactams were obtained as the sole observed products.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560066.
- Supporting Information
-
References and Notes
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