Neuropediatrics 2015; 46(05): 329-334
DOI: 10.1055/s-0035-1558969
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Use of Levetiracetam in Neonates in Clinical Practice: A Retrospective Study at a German University Hospital

Martina P. Neininger
1   Drug Safety Center, Department of Clinical Pharmacy, Institute of Pharmacy, University of Leipzig, Leipzig, Germany
,
Michaela Ullmann
1   Drug Safety Center, Department of Clinical Pharmacy, Institute of Pharmacy, University of Leipzig, Leipzig, Germany
,
Anna J. Dahse
1   Drug Safety Center, Department of Clinical Pharmacy, Institute of Pharmacy, University of Leipzig, Leipzig, Germany
2   Drug Safety Center, Pharmacy of the University Hospital, Leipzig, Germany
,
Steffen Syrbe
3   Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
,
Matthias K. Bernhard
3   Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
,
Roberto Frontini
2   Drug Safety Center, Pharmacy of the University Hospital, Leipzig, Germany
,
Wieland Kiess
3   Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
,
Andreas Merkenschlager
3   Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
,
Ulrich Thome
4   Division of Neonatology, Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
,
Thilo Bertsche*
1   Drug Safety Center, Department of Clinical Pharmacy, Institute of Pharmacy, University of Leipzig, Leipzig, Germany
,
Astrid Bertsche*
3   Centre for Paediatric Research, University Hospital for Children and Adolescents, Leipzig, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

25. März 2015

16. Juni 2015

Publikationsdatum:
26. August 2015 (online)

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Abstract

Objective We performed a retrospective chart analysis in neonates routinely treated with levetiracetam (LEV) in a university setting.

Patients and Methods We assessed clinical characteristics of the included neonates. Documented LEV doses and the duration of treatment were evaluated. To assess LEV effectiveness, we compared the need of any additional anticonvulsant as co- and rescue therapies before and following the initiation of LEV treatment. To assess LEV tolerance, we sought to identify documented adverse drug reactions resulting in a termination of LEV treatment.

Results We analyzed a total of 72 neonates receiving LEV with a median gestational age at initiation of LEV treatment of 30 4/7 gestational weeks (min., 245/7/max., 430/7 weeks). LEV was applied in target doses of 41.7 mg/kg/d (min., 14.4/max., 106.2 mg/kg/d). Patients received LEV treatment at hospital for a median of 28 days (min., 1/max., 195 days). Additional anticonvulsant therapy decreased a week after LEV treatment was initiated (p = 0.008). We did not find any cases of terminated LEV treatment resulting from adverse drug reactions.

Conclusion Long term use of high LEV doses is rather frequent in immature neonates. Our data indicate good effectiveness and a low risk of adverse drug reactions.

* The authors, Thilo Bertsche and Astrid Bertsche, contributed equally to this work.