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Journal of Pediatric Neurology 2008; 06(02): 189-190
DOI: 10.1055/s-0035-1557448
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Proximal tubular renal dysfunction on treatment with valproic acid

Alberto Bettinelli
a   Department of Pediatrics, San Leopoldo Mandic Hospital, Merate-Lecco, Italy
,
Claudio Zucca
b   Scientific Institute E. Medea, Bosisio Parini, Italy
,
Lucia Radice
b   Scientific Institute E. Medea, Bosisio Parini, Italy
,
Sara Stucchi
a   Department of Pediatrics, San Leopoldo Mandic Hospital, Merate-Lecco, Italy
,
Alberto Tettamanti
c   Department of Pediatrics and Neonatology, Valduce Hospital, Como, Italy
,
Mario G. Bianchetti
d   Department of Pediatrics, Mendrisio and Bellinzona, Switzerland
› Author Affiliations
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Further Information

Publication History

27 April 2007

01 January 2008

Publication Date:
30 July 2015 (online)

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Abstract

A 10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.

Keywords

Fanconi syndrome - kidney disease - valproic acid - epilepsy