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J Pediatr Infect Dis 2007; 02(04): 237-240
DOI: 10.1055/s-0035-1557044
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Diarrhea with encephalopathy: A case report

Katherine Hale
a   Departments of Allergy, Immunology and Infectious Diseases, The Children's Hospital at Westmead, Sydney, Australia
,
Neeta Rampersad
b   Department of Medicine, The Children's Hospital at Westmead, Sydney, Australia
,
Elizabeth Elliott
b   Department of Medicine, The Children's Hospital at Westmead, Sydney, Australia
c   Discipline of Paediatrics and Child Health, Faculty of Medicine, the University of Sydney, Sydney, Australia
d   The Australian Pediatric Surveillance Unit, Sydney, Australia
› Author Affiliations
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Publication History

05 December 2006

20 March 2007

Publication Date:
28 July 2015 (online)

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Abstract

We report a case of Salmonella typhimurium encephalopathy in a 7-year-old girl. The patient presented with abrupt onset of coma following a brief history of diarrhea, vomiting and fever. Despite aggressive and appropriate management, she developed acute renal failure and coagulopathy and irreversible neurological compromise. No adequate alternative explanation was found for her disease. A summary of published cases is presented and postulated pathogenic mechanisms are discussed, which includes an endotoxin triggered inflammatory response.

Keywords

Salmonella infections - Salmonella typhimurium - brain diseases