Planta Med 2015; 81 - PX58
DOI: 10.1055/s-0035-1556502

Potential pancreatic lipase inhibitory activity of 2-arylbenzofuran derivatives from Morus alba

BS Min 1, HM Tuan 1, TM Hung 1, JA Kim 2
  • 1College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712 – 702, Korea
  • 2College of Pharmacy, Kyungpook National University, Daegu 702 – 701, Korea

Bioassay-guided isolation of the methanolic extract of Morus alba using pancreatic lipase inhibitory activity led to isolation of five new 2-arylbenzofuran derivatives (4 – 8), three new flavonoids (1, 2, 9), one new prenylated stilbene (3) and twelve known compounds including moracin B (10), moracin E (11), isobavachalcone (12), morusin (13), sanggenol L (14), kuwanon T (15), kuwanon U (16), 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (17), mulberrofuran D (18), sanggenofuran A (19), mulberrofuran D2 (20), and mulberrofuran A (21). Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data. Compounds 5, 7, 18 and 19 showed potent inhibition against pancreatic lipase with IC50 values of 0.564, 0.388, 0.089 and 0.912µM, respectively.