Isolation of sesquiterpene lactones from Trichospiras verticillata

Y Du; Y Dai; P Krai; M Goetz; MB Cassera; DGI Kingston

doi:10.1055/s-0035-1556488

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Planta Med 2015; 81 - PX44
DOI: 10.1055/s-0035-1556488

Isolation of sesquiterpene lactones from Trichospiras verticillata

Y Du ¹, Y Dai ¹, P Krai ², M Goetz ³, MB Cassera ², DGI Kingston ¹

¹Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA
²Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA
³Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, USA

Congress Abstract

A CH₂Cl₂ extract of Trichospiras verticillata from the Natural Products Discovery Institute was found to have good antimalarial activity, with an IC₅₀ value of 5 µg/mL. After purification by liquid-liquid partition, chromatography on Sephadex LH-20, and C-18 reverse phase HPLC, the four new sesquiterpenes 1 – 4 were isolated. The structures of the new compounds were determined by using NMR spectroscopy, MS and CD. Among these four compounds, the conjugated dienone 4 had the most potent antimalarial activity.