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Planta Med 2015; 81 - PX32
DOI: 10.1055/s-0035-1556476
DOI: 10.1055/s-0035-1556476
Cytotoxic sesquiterpenoids from Siegesbeckia glabrescens
Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1 – 4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9 – 33.3µM.
![](https://www.thieme-connect.de/media/plantamedica/201511/10-1055-s-0035-1556476-i113.jpg)
![](https://www.thieme-connect.de/media/plantamedica/201511/10-1055-s-0035-1556476-i114.jpg)