Neolignans and other metabolites from Ocotea cymosa from the Magadascar rain forest and their biological activities

S Fotso; Q Xiong; PR Graupner; HL Rakotondraibe; M Olson; JD Wiley; P Krai; PJ Brodie; MW Callmander; E Rakotobe; F Ratovoson; VE Rasamison; MB Cassera; DR Hahn; DGI Kingston

doi:10.1055/s-0035-1556463

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Planta Med 2015; 81 - PX19
DOI: 10.1055/s-0035-1556463

Neolignans and other metabolites from Ocotea cymosa from the Magadascar rain forest and their biological activities

S Fotso ², Q Xiong ², PR Graupner ², HL Rakotondraibe ¹, M Olson ², JD Wiley ³, P Krai ³, PJ Brodie ¹, MW Callmander ⁴, E Rakotobe ⁵, F Ratovoson ⁴, VE Rasamison ⁵, MB Cassera ³, DR Hahn ², DGI Kingston ¹

¹Department of Chemistry and Virginia Tech Center for Drug Discovery
²Discovery Research, Dow AgroSciences, Zionsville Road, Indianapolis
³Department of Biochemistry and Virginia Tech Center for Drug Discovery
⁴Missouri Botanical Garden, Madagascar
⁵Centre National d'Application des Recherches Pharmaceutiques, Madagascar

Congress Abstract

In the course of investigations on plant derived extracts from Madagascar rain forest against agricultural relevant plants pathogens. The bio-guided isolation on Ocotea cymosa (Lauraceae) yielded ten new neolignans along with seven known compounds. Three compounds exhibited inhibitory activity against Aedes aegypti, while ococymosin, ocobullenone derivative the known ocobullenone and virolongin B showed antiplasmodial activity. This poster highlights the isolation, structure elucidation and biological activities of these compounds.