Antitrypanosomal activity of an iridal from Iris domestica and initial structure-activity relationships

N Dunlap; AL Pathiranage; J Stubblefield; A Newsome

doi:10.1055/s-0035-1556460

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Planta Med 2015; 81 - PX16
DOI: 10.1055/s-0035-1556460

Antitrypanosomal activity of an iridal from Iris domestica and initial structure-activity relationships

N Dunlap ¹^,³, AL Pathiranage ¹, J Stubblefield ², A Newsome ²^,³

¹Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, USA
²Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA
³Tennessee Center for Botanical Medicine Research, Middle Tennessee State University, Murfreesboro, TN 37132, USA

Congress Abstract

The myristate ester of iso-iridogermanal was identified as an antitrypanosomal component of Iris domestica using bioassay-guided fractionation. This compound has previously been isolated from I. domestica, as well as other Iris species, and has been shown to be cytotoxic to tumor cells. Investigation of the antitrypanosomal activity of iso-iridogermanal, as well as semi-synthetic derivatives, will be presented.