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Planta Med 2015; 81 - PW3
DOI: 10.1055/s-0035-1556431
DOI: 10.1055/s-0035-1556431
Flavonoids modulating c-Met and ALK activity
Bioactivity-guided separation of the roots of Scutellaria baicalensis, using c-Met kinase assay, led to the isolation of 19 flavonoids. Of these isolates, norwogonin and baicalin were found to be active in the c-Met assay. Further investigation for c-Met inhibitory compounds in the ALK assay revealed that norwogonin and baicalin were active. Norwogonin and baicalin were found to inhibit both c-Met (IC50 6.24 and 13.4µM, respectively) and ALK kinases (IC50 7.62 and 0.93µM, respectively). Furthermore, the binding mode of norwogonin in the ATP binding site of c-Met was disclosed in docking study.