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Planta Med 2015; 81 - PQ16
DOI: 10.1055/s-0035-1556350
DOI: 10.1055/s-0035-1556350
Isolation of strongylophorines from the marine sponge Petrosia corticata, as proteasome inhibitors
The proteasome is a new oncology target after the approval of Velcade® and we have been searching for new inhibitors from natural sources. Recently, we isolated two new strongylophorines (1 and 2) along with six known congeners (3-8) from the marine sponge Petrosia corticata and measured their inhibitory activities against the chymotrypsin-like activity of the proteasome.