Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 2015; 81 - PE9
DOI: 10.1055/s-0035-1556217
DOI: 10.1055/s-0035-1556217
Anti-cancer activity of some synthesized aromatic oxybutynyl amine derivatives
Twelve aromatic oxybutynyl amine derivatives (1 – 12) were synthesized via Mannich reaction. All synthesized compounds were tested primarily for their anti-leukemic activity against leukemia K562 cells, in a conc. of 10 µg/ml. Compound 9 showed the highest activity of 100% inhibition. Furthermore, compound 9 showed an IC50 value of 0.03 and 0.008 µg/ml against leukemia K562 and HL60 cells respectively, where IC50 value of Taxol against both cells was 0.0023 µg/ml.