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DOI: 10.1055/s-0035-1555996
4D-RV-Function 2—A Promising for Three Dimensional Echocardiographic Datasets in Children and Young Adults?
Introduction: Real-time 3D-Echocardiography (RT3DE) is a promising method to assess right ventricular end diastolic (EDV), end systolic (ESV), stroke (SV) volumes and ejection fraction (EF).
Methods: 20 healthy children and adults (6–40, median 16.4 years, 13 female) were investigated by cardiac magnetic resonance imaging (CMR, 3T Achieva, Philips, Cine SSFP, frame rate 20–24/s) and RT3DE (Vivid 7, IE33, 4-beat acquisition, frame rate 20–30/s). Analysis of CMR data by the summation of disks method, RT3DE data by a prototype of the 4D RV-Function 2 software (Tomtec, Germany). Statistical analysis using Bland Altmann, correlations with Pearson-Bravais.
Results: Feasibility of 90% (18 RT3DE datasets). RT3DE provided mild mean underestimation of EDV (4.5 ± 8,5%, LOA −12.5% to 21.5%, r=0.990), ESV (1.4 ± 15.4%, LOA −29.5% to 32.3%, r=0.951), SV (6.5 ± 12.4%, LOA −18.3% to 31.3%, r=0.974) and EF (2.0 ± 8.9%, LOA −15.8% to 19.8%, r=0.969). Intraobserver-variability for EDV (−1.7 ± 8.2%, LOA −18% to 14.6%, r=0.979) and ESV (2.9 ± 13.2%, LOA −23.5% to 29.3%, r=0.928) was low. Interobserver-variability for EDV (0.8 ± 15%, LOA −29.1% to 30.8%, r=0.928) was better than for ESV (2.0 ± 24%, LOA −46% to 50%, r=0.887). Mean septal longitudinal Strain (LS) −21 ± 5,9%, free wall LS −29 ± 6.5% (p < 0.001). Mean calculation time was 5 minutes.
Conclusion: RV-Function 2 provides good feasibility and promising accuracy in healthy individuals. Reproducibility of ESV estimation was inferior to EDV. Deformational parameters can also be assessed within a short period of calculation time from the same RT3DE dataset. Further validations have to be performed to undermine that the method is an interesting tool for clinical use in patients.