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Int J Sports Med 2015; 36(13): 1035-1040
DOI: 10.1055/s-0035-1555782
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Antioxidants may Attenuate Plasma Erythropoietin Decline after Hyperbaric Oxygen Diving

T. S. Mutzbauer
1   Institute for Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
,
M. Schneider
2   Sektion Experimentelle Anaesthesiologie, University of Ulm, Ulm, Germany
,
B. Neubauer
3   Berufsgenossenschaft für Transport und Verkehrswirtschaft, Referat Arbeitsmedizin/Verkehrsmedizin, Hamburg, Germany
,
M. Weiss
4   Klinik für Anaesthesiologie, University of Ulm, Ulm, Germany
,
K. Tetzlaff
5   Sports Medicine, University of Tuebingen, Tuebingen, Germany
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accepted after revision 26. Mai 2015

Publikationsdatum:
10. August 2015 (online)

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Abstract

According to previous studies, plasma erythropoietin (EPO) may decrease after hyperbaric oxygen exposure due to oxidative stress. It is hypothesized that the decrease of EPO can be attenuated by oxygen free radical scavengers.

The aim of the present study was to evaluate whether EPO plasma levels can be influenced by oral application of vitamin C and E before repeated hyperbaric oxygen exposure during diving. 16 healthy male police task force divers performed 3 morning dives on oxygen within a regular diving schedule on 3 consecutive days. They were randomized into either the placebo group or the vitamin group, receiving 1 g ascorbic acid and 600 IU D-α-tocopherol orally 60 min before the dive. Blood samples for EPO measurement were taken on days 1, 2, and 3 at T1, T3 and T5 60 min before and at T2, T4 and T6 60 min after each dive, respectively. A moderate decrease of EPO was observed beginning at T3 until T6 in the placebo group. The EPO concentrations in the vitamin group did not show relevant variations compared to baseline. Radical scavenging vitamins C and D may counteract hyperbaric oxygen related mechanisms reducing EPO production in hyperbaric oxygen exposure during diving.

Key words

oxygen diving - erythropoietin - antioxidants
 

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