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J Neurol Surg Rep 2015; 76(01): e164-e166
DOI: 10.1055/s-0035-1554933
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Bilateral Chronic Subdural Nontraumatic Hematoma in a Woman Affected by AL Amyloidosis

M. Luongo
1   Department of Neurosurgery, San Carlo Hospital, Potenza, Italy
,
M. Grassi
1   Department of Neurosurgery, San Carlo Hospital, Potenza, Italy
,
U. Godano
1   Department of Neurosurgery, San Carlo Hospital, Potenza, Italy
› Institutsangaben
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Publikationsverlauf

18. März 2015

28. März 2015

Publikationsdatum:
26. Juni 2015 (online)

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Abstract

Chronic subdural hematoma (CSDH) is a condition frequently seen in neurosurgical practice, especially among the elderly. It is often preceded by head injury, even a trivial trauma. Light chain (AL) amyloidosis is a disorder involving extracellular tissue deposition of misfolded native proteins called amyloids. The several types of amyloidosis differ by source of proteins, organ involvement, treatment, and prognosis. We describe the case of a 59-year-old woman affected by AL amyloidosis, harboring surgically treated bilateral chronic nontraumatic subdural hematoma, and we suggest a possible correlation between the clinical entities of CSDH and AL amyloidosis.

Keywords

chronic subdural hematoma - AL amyloidosis - headache - acute subdural bleeding - amyloids - vessel fragility
 

  • References

  • 1 Kyle RA, Linos A, Beard CM , et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood 1992; 79 (7) 1817-1822
    PubMedGoogle Scholar
  • 2 Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003; 349 (6) 583-596
    CrossrefPubMedGoogle Scholar
  • 3 Penchet G, Loiseau H, Castel JP. Chronic bilateral subdural hematomas [in French]. Neurochirurgie 1998; 44 (4) 247-252
    PubMedGoogle Scholar
  • 4 Matsuda M, Gono T, Shimojima Y , et al. AL amyloidosis manifesting as systemic lymphadenopathy. Amyloid 2008; 15 (2) 117-124
    CrossrefPubMedGoogle Scholar
  • 5 Kyle RA, Greipp PR. Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc 1983; 58 (10) 665-683
    PubMedGoogle Scholar
  • 6 Yood RA, Skinner M, Rubinow A, Talarico L, Cohen AS. Bleeding manifestations in 100 patients with amyloidosis. JAMA 1983; 249 (10) 1322-1324
    CrossrefPubMedGoogle Scholar
  • 7 Greipp PR, Kyle RA, Bowie EJ. Factor-X deficiency in amyloidosis: a critical review. Am J Hematol 1981; 11 (4) 443-450
    CrossrefPubMedGoogle Scholar
  • 8 Wettlé C, Springinsfeld G, Lipsker D. Haemorrhage and amyloidosis—response to Veneri et al. Br J Haematol 2013; 160 (6) 854-855
    PubMedGoogle Scholar
  • 9 Mumford AD, O'Donnell J, Gillmore JD, Manning RA, Hawkins PN, Laffan M. Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis. Br J Haematol 2000; 110 (2) 454-460
    CrossrefPubMedGoogle Scholar
  • 10 Veneri D, Pizzolo G, Bonalumi A, Franchini M. Haemorrhage and amyloidosis. Br J Haematol 2013; 160 (6) 854
    PubMedGoogle Scholar
  • 11 Luongo M, Pizzuti M, Godano U. Bilateral chronic subdural non-traumatic hematoma associated with von Willebrand's type I disease: a case report. Acta Neurochir (Wien) 2012; 154 (6) 1087-1088
    CrossrefPubMedGoogle Scholar
  • 12 Luongo M, Pizzuti M, Godano U. Chronic subdural non traumatic hematoma associated with von Willebrand's disease: a real clinical association or just a mere coincidence?. Clin Neurol Neurosurg 2013; 115 (8) 1569-1570
    CrossrefPubMedGoogle Scholar
  • 13 Manikkan AT. Factor X deficiency: an uncommon presentation of AL amyloidosis. Ups J Med Sci 2012; 117 (4) 457-459
    CrossrefPubMedGoogle Scholar