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Journal of Pediatric Biochemistry 2015; 05(01): 012-014
DOI: 10.1055/s-0035-1554731
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Persistent Deficiency for 40% of Toddlers Who Were Vitamin D Deficient as Neonates, Which Cannot Be Assessed by Examining Symptoms of Rickets

Paul Harold George Hogeman
1   Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands
,
Marieke Peternella Hoevenaar-Blom
1   Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands
,
Jos Peter Marie Wielders
2   Department of Clinical Chemistry, Meander Medical Centre, Amersfoort, The Netherlands
› Author Affiliations
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Publication History

Publication Date:
03 July 2015 (online)

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Abstract

We studied a group of 74 toddlers, mean age 16 months, diagnosed with severe vitamin D deficiency at birth (cord blood <20 nmol/L 25OH vitamin D for neonates). Of 74 initially deficient toddlers, 30 did not reach sufficiency at 50 nmol/L level of serum vitamin D, suggesting persistent vitamin D deficiency over on average 16 months. Boys remained deficient more often than girls. Even in severely deficient toddlers (25OH vitamin D <30 nmol/L), no clinical evidence of symptoms of rickets, growth and development retardation, or abnormal serum calcium levels was observed.

Keywords

perinatal - vitamin D deficiency - rickets - toddlers
 

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