Diabetologie und Stoffwechsel 2015; 10 - P194
DOI: 10.1055/s-0035-1549700

Effects of the gestational diabetes-risk polymorphism rs10501320 of MADD gene on metabolic phenotype and glucose homeostasis in women with history of gestational diabetes

N Perakakis 1, L Arend 1, L Potasso 1, A Lamprinou 2, E Polyzou 3, A Kassanos 3, R Rasenack 4, G Päth 1, J Seufert 1, K Laubner 1
  • 1Universitätsklinikum Freiburg, Abteilung für Endokrinologie und Diabetologie, Klinik für Innere Medizin II, Freiburg, Germany
  • 2Universität Tübingen, Medizinische Klinik IV, Tübingen, Germany
  • 3Universitätsklinik Attikon, 3. Abteilung für Geburtshilfe und Gynäkologie, Athen, Greece
  • 4Universitätsklinikum Freiburg, Klinik für Gynäkologie und Geburtshilfe, Freiburg, Germany

Objective: We have recently reported that the insulin-biosynthesis-impairing MADD rs10501320 genetic polymorphism is associated with gestational diabetes (GDM) in a European population. Aim of our study was to investigate the effects of this polymorphism on metabolic phenotype and glucose homeostasis in the same population of women 8 – 12 years after pregnancy.

Methods: We have previously genotyped the G/C polymorphism, rs10501320 in 157 unrelated women with a history of GDM (Germans = 108, Greeks = 49). The women from the German arm were invited 8 – 12 years after pregnancy to participate in a prospective study collecting anthropometric traits and measuring glucose, proinsulin, insulin, c-peptide, glucagon, GLP1, GIP, leptin, adiponectin, TNF-alpha, fetuin A and irisin in a five time-point oral glucose tolerance test (OGTT).

Results: Findings from the first 18 subjects indicate a significantly lower BMI in the homozygous carriers of the risk allele (GG) compared to the heterozygous subjects (GC) [BMI: GG = 24.7 kg/m2, SD = 2.79, GC = 31.6 kg/m2, SD = 4.6, p = 0,0023]. Moreover, GG women, compared to GC ones, demonstrate a non-significant trend to higher glucose levels in 60, 90, 120 min of the OGTT and also to higher proinsulin, c-peptide and insulin values in all the 5-time points (0,30,60,90, 120 min) of the OGTT

Conclusion: The first preliminary results of our on-going-prospective study demonstrate that the rs10501320 gestational diabetes risk polymorphism of MADD affects weight, glucose values and insulin synthesis and secretion in women with history of gestational diabetes.