European J Pediatr Surg Rep. 2015; 03(02): 061-063
DOI: 10.1055/s-0035-1549364
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Management of a Giant Omphalocele with Non–Cross-Linked Intact Porcine-Derived Acellular Dermal Matrix (Strattice) Combined with Vacuum Therapy

Daisy Vieira Travassos
1   Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands
,
Albertien M. van Eerde
2   Department of Medical Genetics, University Medical Center Utrecht, The Netherlands
,
William L.M. Kramer
1   Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands
› Author Affiliations
Further Information

Publication History

04 June 2014

02 March 2015

Publication Date:
26 June 2015 (online)

Abstract

The management of giant omphaloceles at our department is primarily conservative. However, management can be challenging if the omphalocele is ruptured or the sac has to be removed. We report a case in which a giant omphalocele in a newborn female patient was managed by covering the abdominal defect with non–cross-linked intact porcine-derived acellular dermal matrix (Strattice reconstructive tissue matrix, LifeCell Corp., Branchburg, New Jersey, United States) sutured to the fascia combined with vacuum therapy.

Supplementary Material

 
  • References

  • 1 Hurst J, Firth HV, Chitty LS. Syndromic associations with congenital anomalies of the fetal thorax and abdomen. Prenat Diagn 2008; 28 (7) 676-684
  • 2 Porter A, Benson CB, Hawley P, Wilkins-Haug L. Outcome of fetuses with a prenatal ultrasound diagnosis of isolated omphalocele. Prenat Diagn 2009; 29 (7) 668-673
  • 3 Brunner HG, Hamel BC, Bokhoven Hv Hv. P63 gene mutations and human developmental syndromes. Am J Med Genet 2002; 112 (3) 284-290
  • 4 Firth HV, Richards SM, Bevan AP , et al. DECIPHER: Database of chromosomal imbalance and phenotype in humans using ensembl resources. Am J Hum Genet 2009; 84 (4) 524-533
  • 5 Saller Jr DN, Canick JA, Palomaki GE, Knight GJ, Haddow JE. Second-trimester maternal serum alpha-fetoprotein, unconjugated estriol, and hCG levels in pregnancies with ventral wall defects. Obstet Gynecol 1994; 84 (5) 852-855
  • 6 Gabriel A, Gollin G. Management of complicated gastroschisis with porcine small intestinal submucosa and negative pressure wound therapy. J Pediatr Surg 2006; 41 (11) 1836-1840
  • 7 Kilbride KE, Cooney DR, Custer MD. Vacuum-assisted closure: a new method for treating patients with giant omphalocele. J Pediatr Surg 2006; 41 (1) 212-215
  • 8 Wilcinski SL. Use of a vacuum-assisted device in a neonate with a giant omphalocele. Adv Neonatal Care 2010; 10 (3) 119-126 , quiz 127–128
  • 9 Campbell KT, Burns NK, Rios CN, Mathur AB, Butler CE. Human versus non-cross-linked porcine acellular dermal matrix used for ventral hernia repair: comparison of in vivo fibrovascular remodeling and mechanical repair strength. Plast Reconstr Surg 2011; 127 (6) 2321-2332
  • 10 Byrd Jr JF, Agee N, Getz SB, Lincourt AE, Iannitti DA, Heniford BT. Evaluation of porcine-derived grafts (XenMatrix, Strattice, and Permacol) in an in vivo preclinical study [abstract]. In: Proceedings of the 90th Annual Meeting of the American Association of Plastic Surgeons; April 9–12, 2011; Boca Raton, FL
  • 11 Connor J, McQuillan D, Sandor M , et al. Retention of structural and biochemical integrity in a biological mesh supports tissue remodeling in a primate abdominal wall model. Regen Med 2009; 4 (2) 185-195
  • 12 Sandor M, Xu H, Connor J , et al. Host response to implanted porcine-derived biological materials in a primate model of abdominal wall repair. Tissue Eng Part A 2008; 14 (12) 2021-2031