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Zeitschrift für Orthomolekulare Medizin 2015; 4(04): 9-15
DOI: 10.1055/s-0035-1547588
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© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Das Ultraspurenelement Bor

Uwe Gröber
,
Klaus Kisters
Further Information

Publication History

Publication Date:
27 January 2016 (online)

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Zusammenfassung

Bor wird bisher als nichtessenzielles Spurenelement bewertet. Es deuten sich aber positive Wirkungen im Knochenstoffwechsel, bei entzündlichen Gelenkerkrankungen sowie bei der Gehirnfunktion an. Möglicherweise hat Bor zudem einen günstigen Einfluss auf das individuelle Krebsrisiko. Bisher fehlen jedoch noch umfangreiche Studien, um die bisher vorliegenden Daten zu untermauern.

Schlüsselwörter

Bor - Ernährung - Wirkmechanismen - Knochenstoffwechsel - Osteoporose - Arthrose - Osteoarthritis - Gehirnfunktion - Prostatakarzinom
 

  • Literatur

  • 1 Bahadir M, Parlar H, Spitteler M Hrsg. Springer Umweltlexikon. 2. Aufl Berlin, Heidelberg, New York: Springer; 2000
    CrossrefSearch in Google Scholar
  • 2 Greenwood NN, Earnshaw A. Chemie der Elemente. Weinheim: VCH Verlagsgesellschaft; 1988
    Search in Google Scholar
  • 3 Mengel K. Ernährung und Stoffwechsel der Pflanze. 7. überarbeitete Aufl. Jena: Gustav Fischer; 1991
    Search in Google Scholar
  • 4 Nielsen FH. Ultratrace elements of possi­ble importance for human health: an update. Prog Clin Biol Res 1993; 380: 355-376
    Search in Google Scholar
  • 5 Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1(5): 394-397
    Search in Google Scholar
  • 6 Nielsen FH. Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 1994; 102(Suppl 7): 59-63
    CrossrefSearch in Google Scholar
  • 7 Nielsen FH, Shuler TR, Zimmerman TJ, Uthus EO. Magnesium and methionine deprivation affect the response of rats to boron deprivation. Biol Trace Elem Res 1988; 17: 91-107
    CrossrefSearch in Google Scholar
  • 8 Hunt CD, Nielsen FH. Interactions of dietary boron, magnesium and cholecalciferol in the chick. Proc N D Acad Sci 1987; 41: 50
    Search in Google Scholar
  • 9 Hunt CD. Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biol Trace Elem Res 1989; 22(2): 201-220
    CrossrefSearch in Google Scholar
  • 10 Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. Open Orthop J 2012; 6: 143-149
    CrossrefSearch in Google Scholar
  • 11 Uysal T, Ustdal A, Sonmez MF, Ozturk F. Stimulation of bone formation by dietary boron in an orthopedically expanded suture in rabbits. Angle Orthod 2009; 79(5): 984-990
    CrossrefSearch in Google Scholar
  • 12 Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Med Biol 2010; 24(4): 243-250
    CrossrefSearch in Google Scholar
  • 13 Taşlı PN, Doğan A, Demirci S, Şahin F. Boron enhances odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs) in vitro. Biol Trace Elem Res 2013; 153(1-3): 419-427
    CrossrefSearch in Google Scholar
  • 14 Nielsen FH, Hunt CD, Mullen LM et al. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1(5): 394-397
    Search in Google Scholar
  • 15 Nielsen FH, Mullen LM, Gallagher SK. Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet. J Tr Elem Exp Med 1990; 3: 45-54
    Search in Google Scholar
  • 16 Naghii MR, Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res 1997; 56(3): 273-286
    CrossrefSearch in Google Scholar
  • 17 Naghii MR, Mofid M, Asgari AR et al. , Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol 2011; 25(1): 54-58
    CrossrefSearch in Google Scholar
  • 18 Ferrando AA, Green NR. The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders. Int J Sport Nutr 1993; 3(2): 140-149
    Search in Google Scholar
  • 19 Hunt CD, Herbel JL, Nielsen FH. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: ­boron, calcium, and magnesium absorption and retention and blood mineral concen­trations. Am J Clin Nutr 1997; 65(3): 803-813
    Search in Google Scholar
  • 20 Scorei RI, Rotaru P. Calcium fructoborate – potential anti-inflammatory agent. Biol Trace Elem Res 2011; 143(3): 1223-1238
    CrossrefSearch in Google Scholar
  • 21 Rogoveanu OC, Mogoşanu GD, Bejenaru C et al. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study. Biol Trace Elem Res 2015; 163(1–2): 124-131
    CrossrefSearch in Google Scholar
  • 22 Scorei R, Mitrut P, Petrisor I, Scorei I. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biol Trace Elem Res 2011; 144(1–3): 253-263
    CrossrefSearch in Google Scholar
  • 23 Pietrzkowski Z, Phelan MJ, Keller R et al. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. Clin Interv Aging 2014; 9: 895-899
    Search in Google Scholar
  • 24 Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect 1994; 7: 83-85
    Search in Google Scholar
  • 25 Fracp RL, Rennie GC, Newnham RE. Boron and arthritis: the results of a double-blind pilot study. J Nutr Med 1990; 1: 127-132
    CrossrefSearch in Google Scholar
  • 26 Penland JG. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res 1998; 66(1–3): 299-317
    CrossrefSearch in Google Scholar
  • 27 Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect 1994; 102(Suppl 7): 65-72
    CrossrefSearch in Google Scholar
  • 28 Penland JG. Quantitative analysis of EEG effects following experimental magnesium and boron deprivation. Magnes Res 1995; 8(4): 341-358
    Search in Google Scholar
  • 29 Penland JG, Eberhardt MJ. Effects of dietary boron and magnesium on brainfunction of mature male and female Long-Evans rats. J Trace Elem Exp Med 1993; 6: 53-64
    Search in Google Scholar
  • 30 Nielsen FH, Penland JG. Boron deprivation alters rat behavior and brain mineralcomposition differently when fish oil instead of safflower oil is the diet fatsource. Nutr Neurosci 2006; 9: 105-112
    CrossrefSearch in Google Scholar
  • 31 Cui Y, Winton MI, Zhang ZF et al. Dietary boron intake and prostate cancer risk. Oncol Rep 2004; 11(4): 887-892
    Search in Google Scholar
  • 32 Zha J, Lackner MR. Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy. Clin Cancer Res 2010; 16(9): 2512-2517
    CrossrefSearch in Google Scholar
  • 33 Gallardo-Williams MT, Chapin RE, King PE et al. Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Toxicol Pathol 2004; 32(1): 73-78
    CrossrefSearch in Google Scholar
  • 34 Barranco WT, Eckhert CD. Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett 2004; 216(1): 21-29
    CrossrefSearch in Google Scholar
  • 35 Barranco WT, Eckhert CD. Cellular changes in boric acid-treated DU-145 prostate cancer cells. Br J Cancer 2006; 94(6): 884-890
    CrossrefSearch in Google Scholar
  • 36 Barranco WT, Hudak PF, Eckhert CD. Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States). Cancer Causes Control 2007; 18(1): 71-77
    CrossrefSearch in Google Scholar
  • 37 Scorei R, Ciubar R, Ciofrangeanu CM et al. Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biol Trace Elem Res 2008; 122(3): 197-205
    CrossrefSearch in Google Scholar
  • 38 Korkmaz M, Uzgören E, Bakirdere S et al. Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells. Environ Toxicol 2007; 22(1): 17-25
    CrossrefSearch in Google Scholar
  • 39 Mahabir S, Spitz MR, Barrera SL et al. Dietary boron and hormone replacement therapy as risk factors for lung cancer in women. Am J Epidemol 2008; 167(9): 1070-1080
    CrossrefSearch in Google Scholar
  • 40 Korkmaz M, Avcı CB, Gunduz C et al. Disodium pentaborate decahydrate (DPD) induced apoptosis by decreasing hTERT enzyme activity and disrupting F-actin organization of prostate cancer cells. Tumour Biol 2014; 35(2): 1531-1538
    CrossrefSearch in Google Scholar
  • 41 Henderson KA, Kobylewski SE, Yamada KE, Eckhert CD. Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells. Biometals 2015; 28(1): 133-141
    CrossrefSearch in Google Scholar
  • 42 Ralston NV, Hunt CD. Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis. Biochim Biophys Acta 2001; 1527: 20-30
    CrossrefSearch in Google Scholar
  • 43 Loenen WAM. S-adenosylmethionine: jack of all trades and master of everything. Biochem Soc Trans 2006; 34: 330-333
    CrossrefSearch in Google Scholar
  • 44 Chen X, Schauder S, Potier N et al. Structural identification of a bacterial quorum-sensing signal containing boron. Nature 2002; 415(6871): 545-549
    CrossrefSearch in Google Scholar
  • 45 Henderson K, Stella SL, Kobylewski S, Eckhert CD. Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells. PLoS One 2009; 4(6): e6009
    CrossrefSearch in Google Scholar
  • 46 Hunt CD, Shuler TR, Mullen LM. Concentration of boron and other elements in human foods and personal-care products. J Am Diet Assoc 1991; 91(5): 558-568
    Search in Google Scholar
  • 47 Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.. Institute of Medicine (US) Panel on Micronutrients Washington (DC): National Academies Press (US); 2001
    Search in Google Scholar
  • 48 Nielsen FH, Penland J. Boron supplementation of peri-menopausal women affects boron metabolism and indices associated with macromineralmetabolism, hormonal status and immune function. Trace Elem Exp Med 1999; 12: 251-261
    Search in Google Scholar
  • 49 Dourson M, Maier A, Meek B et al. Re-evaluation of toxicokinetics for data-derived uncertainty factors. Biol Trace Elem Res 1998; 66(1–3): 453-463
    CrossrefSearch in Google Scholar
  • 50 Peng X, Lingxia Z, Schrauzer GN, Xiong G. Selenium, boron, and germanium deficiency in the etiology of Kashin-Beck disease. Biol Trace Elem Res 2000; 77(3): 193-197
    CrossrefSearch in Google Scholar
  • 51 Ning Y, Wang X, Wang S et al. Is It the Appropriate Time to Stop Applying Selenium Enriched Salt in Kashin-Beck Disease Areas in China. Nutrients 2015; 7(8): 6195-6212
    CrossrefSearch in Google Scholar
  • 52 Scorei ID, Scorei RI. Calcium fructoborate helps control inflammation associated with diminished bone health. Biol Trace Elem Res 2013; 315-321
    Search in Google Scholar
  • 53 Garland CF, Kim JJ, Mohr SB et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014; 104(8): e43-e50
    CrossrefPubMedSearch in Google Scholar
  • 54 Re-evaluation of boric acid (E 284) and sodium tetraborate (E 285) as food additives. EFSA Journal 2013; 11(10): 3407
    Search in Google Scholar
  • 55 Amtsblatt der Europäischen Union, 5.8.2010, Berichtigung der Verordnung (EG) Nr. 1170/2009 der Kommission vom 30. November 2009 Anhang 1, Vitamine und Mineralstoffe, die bei der Herstellung von Nahrungsergänzungsmitteln verwendet werden dürfen.