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Int J Sports Med 2015; 36(10): 832-836
DOI: 10.1055/s-0035-1547218
Immunology
© Georg Thieme Verlag KG Stuttgart · New York

Increased Circulating Anti-inflammatory Cells in Marathon-trained Runners

K. Rehm
1   Department of Medicine, University of Mississippi Medical Center, Jackson, United States
,
I. Sunesara
2   Center for Biostatistics, University Of Mississippi Medical Center, Jackson, United States
,
G. D. Marshall
1   Department of Medicine, University of Mississippi Medical Center, Jackson, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 27 January 2015

Publication Date:
03 June 2015 (online)

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Abstract

Exercise training can alter immune function. Marathon training has been associated with an increased susceptibility to infectious diseases and an increased activity of inflammatory-based diseases, but the precise mechanisms are unknown. The purpose of this study was to compare levels of circulating CD4 +  T cell subsets in the periphery of marathon-trained runners and matched non-marathon controls. 19 recreational marathoners that were 4 weeks from running a marathon and 19 demographically-matched healthy control subjects had the percentage of CD4 +  T cell subpopulations (T helper 1, T helper 2, T helper 1/T helper 2 ratio, regulatory T cells, CD4+IL10+, and CD4+TGFβ+ (Transforming Growth Factor-beta) measured by flow cytometry. Marathon-trained runners had significantly less T helper 1 and regulatory T cells and significantly more T helper 2, CD4 + IL10 + , and TGFβ +  cells than the control subjects. The alterations in the percentage of T helper 1 and T helper 2 cells led to a significantly lower T helper 1/T helper 2 ratio in the marathon-trained runners. These data suggest that endurance-based training can increase the number of anti-inflammatory cells. This may be a potential mechanism for the increased incidence of both infectious and inflammatory diseases observed in endurance athletes.

Keywords

immunology - T cell - cytokine - intracellular cytokine staining
 

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