Objective: This study aims to investigate the outcome of patients who have undergone vestibular
nerve lesioning by Gentamicin injection before surgery to decrease postoperative morbidity
especially balance problem. Also, we aimed to see the effect of lesioning on other
outcome measures.
Patients and Methods: We applied lesioning (preoperatively) for 17 patients who operated for vestibular
schwannoma between 2000 and 2010 at Lund University Hospital. Then, we compared their
outcomes with control group, matched by age, sex, and tumor size. Balance problem
as reported by patients, Eq. 5D,KS,neurological score, and work status data were obtained
and analyzed for both the groups.
Results: Gentamicin injection showed significant difference between both the groups in balance
and Eq. 5D components, with better result for gentamicin group. Whereas other outcome
measures did not show significant difference between both groups.
Conclusion: Vestibular nerve lesioning by gentamicin could be helpful in preventing postoperative
balance problem and improving quality of life.
