Planta Med 2015; 81 - PC9
DOI: 10.1055/s-0035-1545196

Phenyl alkanoid glycosides and steroidal saponins from Panicum turgidum

AA Zaki 1, 3, YA El-Amier 2, Z Ali 3, SI Khan 3, IA Khan 3
  • 1Pharmacognosy Department, Faculty of Pharmacy, Mansoura University
  • 2Botany Department, Ecology, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
  • 3National Center for Natural Product Research, University of Mississippi, University, MS 38677, USA

Panicum turgidum Forssk. (Poaceae) is a perennial desert grass from the Nile region of Egypt, Mediterranean coastal strip, Red sea coastal strip and oases. The geographical distribution of P. turgidum includes many arid sites within a belt of Africa and the Middle East extending between latitude 17 ° W and 88 ° E. The methanol extract of P. turgidum was evaluated for anti-inflammatory activity in a cell-based assay that determined the inhibition of iNOS. The crude extract inhibited iNOS with an IC50 of 56.5 µg/mL in comparison with parthenolide (IC50 of 0.76 µg/mL) as standard compound. The phytochemical investigation of ethyl acetate and aqueous fractions of methanolic extracts of P. turgidum resulted in the isolation of phenyl alkanoid glycosides and steroidal saponins. The structures of isolated compounds were elucidated on the basis of extensive analyses of spectroscopic data including 1D and 2D NMR and ESI-MS.

Fig. 1