Synergism of betulin with antibiotics against some clinical bacterial isolates

T Ali; OM Bello; A Ahmed

doi:10.1055/s-0035-1545186

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Planta Med 2015; 81 - PB31
DOI: 10.1055/s-0035-1545186

Synergism of betulin with antibiotics against some clinical bacterial isolates

T Ali ¹, OM Bello ², A Ahmed ³

¹Department of Applied Chemistry, Federal University Dutsin-Ma, Katsina, Nigeria
²National Center for Natural Products Research, School of Pharmacy, the University of Mississippi, University, Mississippi 38677, USA
³Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria

Congress Abstract

Betulin (Lup-20(29)-ene-3β, 28-diol) is a lupeol-type triterpenoid known to possess antiviral, antibacterial, antiprotozoal, anti-inflammatory and antitumor properties. In order to potentiate the activity of some antibiotics by betulin, sourced from Ampelocissus grantii plants, synergistic studies were carried out in our ongoing research to develop multi-target drugs using phytochemical-antibiotic interactions. The selected triterpenoid was combined with 6 antibiotics against twelve bacterial isolates using a modified microdilution checkerboard protocol. Promising interactions were obtained especially with the combination of betulin with ciprofloxacin, tetracycline or erythromycin. Results of these synergistic effects will be presented.