Planta Med 2015; 81 - PB27
DOI: 10.1055/s-0035-1545182

Phytochemical and biological studies on Ziziphora bungeana

K Zhaparkulova 1, R Srivedavyasasri 2, Z Sakipova 1, SA Ross 2, 3
  • 1Department of Pharmacy, Asfendiyarov Kazakh National Medical University. Almaty 050000, Republic of Kazakhstan
  • 2National Center for Natural Products Research
  • 3Departmant of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA

The genus Ziziphora L. (Lamiaceae) comprises about 30 species wide spread over Asia, Africa and Europe. The plant Ziziphora bungeana Jus. is distributed mainly in Kazakhstan and Central Asia. It is widely used in Kazakh folk medicine for the treatment of hypertension, and cardiovascular diseases. The composition of volatile oil prepared by hydrodistillation from the areal parts of Z. bungeana, was determined by GC/MS analysis. The major components were identified as: pulegone (58.30%), isomenthone (13.49%), menthone (6.71%), α-limonene (5.79%), isopulegone (5.01%), isomenthol (2.63%), β-pinene (1.44%) and α-pinene (1.04%). Bioassay-guided fractionation of the supercritical fluid extract of Z. bungeana lead to the isolation of oleic acid, betulin, β-sitosterol, glyceryl 1,3-dilinoleate and a triterpene (I). The chemical structure of I was determined on the basis of its 1D, 2D NMR and HRMS spectral data to be 3β-acetoxyolean-11-en-28,13β-olide. This is the first report for the isolation of compound I from natural source.

Fig. 1