Exploring for new secondary metabolites with pharmacological potential from the mangroves of southern coast of China

The secondary metabolites found in Mangroves represent an extremely rich source of novel chemical diversity for academic drug discovery and chemical biology programs. It is particularly true that the mangroves from the southern coast of China are very prolific producers of bioactive natural products.

Our group at SIMM has long been engaged in the search for novel secondary metabolites with pharmacological potential from Chinese mangrove plants. In collaboration with biologists and pharmacologists at SIMM, many mangroves were chemically analyzed and numerous novel isolates obtained were pharmacologically screened for activity in a variety of cell-based and pure enzyme assays designed to identify promising lead compounds for the development of drugs in the therapy of human diseases.This presentation will discuss examples of bioactive metabolites (structures and activities) from our most recent discoveries.