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DOI: 10.1055/s-0034-1396421
Advances in the Surgical Treatment of Neuroblastoma: A Review
Publication History
27 October 2014
28 October 2014
Publication Date:
08 December 2014 (online)
![](https://www.thieme-connect.de/media/ejps/201406/lookinside/thumbnails/10.1055-s-0034-1396421-1.jpg)
Abstract
Neuroblastoma prognosis varies tremendously based on the stage and biologic features of the tumor. Treatment varies depending on the risk group and can range from surgery alone for stage 1 tumors to aggressive multimodality treatment for MYCN-amplified tumors. Although surgery plays a role in the diagnosis and management of all stages of neuroblastoma, the importance of that role, especially the extent of resection, in high-risk neuroblastoma continues to evolve. In the past five years, there have been several advances in neuroblastoma surgery. Studies have demonstrated that patients with low-risk disease can be treated with surgery alone, and in a subset of patients who are neonatally diagnosed with adrenal tumors, surgery can be avoided in 80%. Recent abstracts have supported a role for >90% resection of the primary tumor in high-risk patients. This article also reviews the surgical approaches to difficult thoracic and abdominal tumors, as well as the role for minimally invasive surgery in the management of localized neuroblastoma.
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